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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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类固醇类激素GC-MS分析中酮基衍生化技术研究进展
, PP. 743-751
Keywords: 类固醇类激素,酮基,衍生化,气相色谱-质谱联用
Abstract:
类固醇类激素以其独特的生理生化效应而备受关注,气相色谱-质谱联用技术已经成为类固醇类激素分析检测的重要手段。由于类固醇类激素含有羟基、酮基等极性官能团,GC-MS分析时检测灵敏度不高,色谱分离峰形差,需通过衍生化技术将其转化成极性较低、易挥发、热稳定性高的化合物,以改善色谱分离峰形、提高检测灵敏度,使之适用于GC-MS痕量分析。目前,类固醇类激素羟基等含有活性氢原子官能团的衍生化技术发展较为成熟,但酮基衍生化仍缺乏系统研究。本文对类固醇类激素酮基衍生化技术研究进展进行了综述,主要介绍了烯醇化-硅烷化、肟化-硅烷化等酮基衍生化技术的反应原理、应用现状,并对目前存在的问题及进一步的研究方向进行了讨论和展望,为类固醇类激素酮基衍生化技术的研究提供参考。
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