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OALib Journal期刊
ISSN: 2333-9721
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基质与样品的相互作用对于傅立叶变换离子回旋共振质谱测定低分子量多肽的影响
DOI: 10.3724/SP.J.1096.2012.01361, PP. 421-426
Keywords: 基质辅助激光解析电离,傅立叶变换离子回旋共振质谱,肽,薄层法,干滴法
Abstract:
通过比较两种极性差异较大的基质2,5-二羟基苯甲酸(DHB)和2',6'-二羟基苯乙酮(DHAP)按不同比例混合时,AngiotensinⅡ的基质辅助激光解析电离-傅立叶变换离子回旋共振质谱(MALDI-FT/ICRMS)谱图的不同,并结合基质-AngiotensinⅡ在不同结晶方式下的共结晶和基质晶体的扫描电镜照片,发现基质为10μmol/LDHB和15μmol/LDHAP以体积比4:1组成的混合物时,基质结晶为致密的层状结构,而以薄层法与AngiotensinⅡ生成的共结晶,AngiotensinⅡ在基质晶体上面形成分散的柱状小晶体,此时得到的MALDI-FT/ICRMS质谱图优于干滴法。
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