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ERK阻滞剂U0126对白血病细胞K562细胞周期的作用及机制

, PP. 393-395

Keywords: 白血病,细胞周期,ERK,K细胞,U

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Abstract:

目的研究细胞外信号调节激酶(extracellularsignal?regulatedkinase,ERK)阻滞剂U0126对K562细胞周期的作用及机制。方法以逆转录-聚合酶链反应(reversetranscription-polymerasechainreaction,RT-PCR)和Westernblot检测U0126处理K562细胞后ERK、CyclinD2、CyclinE、P27mRNA和蛋白的表达;以流式细胞术(flowcytometry,FCM)检测细胞周期的变化。结果处理后K562细胞ERK、CyclinD2、CyclinEmRNA和蛋白表达降低;P27mRNA和蛋白表达增高。G0/G1期细胞增多,S期细胞减少,与用药前相比差异均有统计学意义(P<0.05)。结论U0126可能通过ERK途径,影响细胞周期调控蛋白,最终抑制了K562细胞的增殖。

References

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