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蛋白芯片联合检测5项结核抗体在结核病诊断中的价值

, PP. 220-222

Keywords: 结核分枝杆菌,结核抗体,蛋白芯片

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Abstract:

目的探讨结核分枝杆菌抗LAM、38kD、16kD、CFP10、ESAT-65项抗体的检测对临床的应用价值。方法检测50例结核病、80例非结核病患者血清,应用蛋白芯片识别仪检测受试者血清中5项结核抗体,并对诊断试验结果进行分析评价。结果130例临床标本显示,以任一抗体检测阳性诊断为结核病阳性,则诊断结核病的灵敏度为92.0%,特异度为77.5%,正确率为83.1%,Youden指数为69.5%。结论蛋白芯片联合检测5项结核抗体具有较高的诊断价值,与“金标准”诊断的一致性较好,且取材简易、操作方便、历时较短,可以作为临床上诊断结核病特别是肺外结核病的一项重要辅诊项目。

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