全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

多药耐药基因1C3435T多态性对汉族儿童外周血单个核细胞mRNA表达的影响

, PP. 1635-1637

Keywords: 多药耐药基因1,单核苷酸多态性,mRNA表达,实时荧光定量PCR

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探讨多药耐药基因1(multidrugresistancegene1,MDR1)C3435T多态性与健康汉族儿童外周血单个核细胞中mRNA表达的关系。方法以130例(男性83例,女性47例)无亲缘关系的中国健康汉族儿童为研究对象,采用PCR-RFLP技术检测其MDR1基因C3435T位点的基因型,实时荧光定量PCR法检测其外周血单个核细胞中MDR1mRNA表达水平。结果130例儿童中,51例为CC型,63例为CT型,16例为TT型,基因型频率分布符合Hardy-Weinberg平衡(P>0.05);CC、CT、TT各基因型组间外周血单个核细胞MDR1mRNA表达水平差异无统计学意义(P>0.05)。结论汉族儿童中MDR1基因C3435T多态性对外周血单个核细胞中mRNA表达无显著性影响。汉族儿童C3435T位点多态性不能作为推测MDR1表达水平的依据。?

References

[1]  柏景坪,王红健,付洁,等.肿瘤坏死因子-α单核苷酸多态性与口腔扁平苔藓的相关性研究[J].第三军医大学学报,2012,34(17):1737.  Bai Jingping,Wang Hongjian,Fu Jie,et al.Correlation of TNF-α polymorphism and oral lichen planus susceptibility: report of 151 cases[J].J Third Mil Med Univ,2012,34(15):1737. [2]吴立强,陈建平,何念海,等.TIM-3基因多态性与儿童咳嗽变异性哮喘的关系[J].第三军医大学学报,2012,34(22):2302.  Wu Liqiang,Chen Jianping,He Nianhai,et al.Relationship between TIM-3 polymorphism and childhood cough variant asthma[J].J Third Mil Med Univ,2012,34(15):2302. [3]唐敏,戴勇,蔡晓钟,等.寡核苷酸微阵列法检测冠心病患者心血管易感基因SNPs[J].第三军医大学学报,2007,29(17):1727. [4]段朝霞,朱佩芳,王正国,等.TLR4基因3′未翻译区内11 367位点突变对荧光素酶表达的影响[J].第三军医大学学报,2006,28(21):2115. [5]钟芳芳,蒋利萍,沈文婷,等.STAT3基因多态性与重庆地区汉族儿童川崎病易感性的关系[J].第三军医大学学报,2013,35(05):456.  Zhong Fangfang,Jiang Liping,Shen Wenting,et al.Association of polymorphism of STAT3 gene with susceptibility Kawasaki disease in Chongqing, China[J].J Third Mil Med Univ,2013,35(15):456. [6]万茜茜,周波,范晶,等.脂肪量和肥胖相关因子基因rs9939609多态性与2型糖尿病的关系研究[J].第三军医大学学报,2010,32(10):1091.  Wan Qianqian,Zhou Bo,Fan Jing,et al.Correlation of human FTOgene rs9939609 polymorphism with type 2 diabetes[J].J Third Mil Med Univ,2010,32(15):1091. [7]欧文君,姚珍薇,骆建云,等.雌激素受体2基因多态性与绝经后女性骨密度的相关性研究[J].第三军医大学学报,2010,32(01):81.  Ou Wenjun,Yao Zhenwei,Luo Jianyun,et al.Estrogen receptor beta gene polymorphisms is correlated with bone mineral density in postmenopausal women[J].J Third Mil Med Univ,2010,32(15):81. [8]丁艳辉,柳青,雷寒.SLC22A3-LPAL2-LPA基因单核苷酸多态性与冠心病的关系研究[J].第三军医大学学报,2010,32(22):2394.  Ding Yanhui,Liu Qing,Lei Han.Association of single nucleotide polymorphism rs2048327-rs3127599-rs7767084-rs10755578 on chromosome 6q26-q27 with coronary artery disease in Chinese Han population[J].J Third Mil Med Univ,2010,32(15):2394. [9]梅英,杜伟,丁雄,等.靶向重组腺病毒载体逆转肝癌细胞多药耐药的实验研究[J].第三军医大学学报,2009,31(15):1462.  MEI Ying,DU Wei,DING Xiong,et al.Experimental study of the targeting recombinant adenoviral vector in reversing the mdr hepatocarcinoma cells[J].J Third Mil Med Univ,2009,31(15):1462. [10]朱沂,张晓莉,张忠辉,等.利用全基因组SNP芯片筛查2型糖尿病患者大血管病变易感基因[J].第三军医大学学报,2011,33(04):331.  Zhu Yi,Zhang Xiaoli,Zhang Zhonghui,et al.Screening macroangiopathy susceptibility genes in type 2 diabetes mellitus patients with whole genome-wide SNP array[J].J Third Mil Med Univ,2011,33(15):331.
[2]  冯毅,肖剑文,郑启城,等. 多药耐药基因1 C3435T多态性对汉族儿童外周血单个核细胞mRNA表达的影响[J].第三军医大学学报,2010,32(15):1635-1637.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133