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氧化应激上调IL-17水平在Graves眼病中的意义

, PP. 1068-1070

Keywords: 氧化应激,白细胞介素,Graves眼病

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Abstract:

目的研究氧化应激及细胞因子白细胞介素17(IL-17)在Graves眼病(Gravesophthalmopathy,GO)发病中的作用。方法收集15例正常对照组和25例初发Graves眼病病例组外周血,检测血清中丙二醛(MDA)、超氧化物歧化酶(SOD)以及IL-17水平。从正常对照和病例组中各选取10例,采外周血分离T淋巴细胞,每例标本均分为空白对照组(H2O2=0,VitC=0)、过氧化氢组(H2O2=1000nmol/L,VitC=0)、维生素C组(H2O2=0,VitC=25μmol/L)、过氧化氢+维生素C组(H2O2=1000nmol/L,VitC=25μmol/L)。体外培养后检测细胞培养上清液IL-17水平并进行统计分析。?结果?①GO病例组血清MDA、IL-17明显高于正常对照组(P<0.05),SOD水平及SOD/MDA显著低于正常对照组(P<0.05),且IL-17与MDA呈显著正相关(r=0.527,P<0.01);②T淋巴细胞培养上清液IL-17水平检测分析,GO病例组中H22组显著高于空白对照组、VitC组及H2O2+VitC组(P<0.05);VitC组及H2O2+VitC组均明显低于空白对照组(P<0.05)。正常对照者各组间无显著差异(P>0.05)。结论氧化应激可诱导GO患者T淋巴细胞分泌IL-17,抗氧化剂VitC可在一定程度减少IL-17释放。

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