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三氧化二砷对人乳腺癌雌激素受体蛋白表达的影响

, PP. 428-430

Keywords: 三氧化二砷,乳腺肿瘤,雌激素受体

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Abstract:

目的本实验通过三氧化二砷(As2O3)对人雌激素受体-α(estrogenreceptoralpha,Erα)阴性乳腺癌细胞株MDA-MB-231进行药物诱导,使其重新表达ERα的可能性及机制。方法用含As2O3终浓度分别为0.5、2.0、4.0μmol/L的1640培养液连续培养MDA-MB-231细胞72h。以不加药同期培养的231细胞作为阴性对照,以MCF-7为阳性对照。分别用Westernblot和免疫组化法检测ERα蛋白的重新表达情况。结果①Westernblot检测结果证实经2.0、4.0μmol/LAs2O3处理的MDA-MB-231细胞组在相对分子质量66000处显示出ERα蛋白带。②免疫组织化学结果显示:0.5μmol/L组阳性染色细胞<10%,与阴性对照组比较差异无统计学意义(P=0.064);2.0μmol/L组阳性染色细胞>70%,与阴性对照组比较差异有统计学意义(P=0.001);4.0μmol/L组阳性染色细胞>40%,与阴性对照组比较差异有统计学意义(P=0.03)。结论适当浓度As2O3能诱导ERα蛋白表达,可以使雌激素受体阴性的乳腺癌细胞重新表达雌激素受体。

References

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