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大鼠大脑皮层神经元缺氧后细胞凋亡情况的动态观察

, PP. 2489-2492

Keywords: 神经元,缺氧,凋亡,电镜

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Abstract:

目的观察大鼠大脑皮层神经元缺氧后细胞凋亡动态变化。方法制备大鼠大脑皮层神经元体外原代培养模型,免疫细胞化学鉴定大鼠大脑皮层神经元,透射电镜下观察不同时间点各实验组神经元超微结构的变化,TUNEL法观察不同时间点各实验组神经元凋亡情况。结果正常对照组神经元透射电镜下形态及染色质正常、内质网、线粒体等结构正常,缺氧组神经元水肿,细胞器破坏或消失;TUNEL法检测神经元凋亡:缺氧后各组神经元凋亡明显增加,与相应正常对照组相比有显著差异(P<0.01),缺氧48h神经元凋亡达高峰(IOD为0.187±0.007),与缺氧12、24h及72h相比有显著差异(P<0.01)。结论细胞凋亡在缺血、缺氧性脑损伤中呈动态变化,是神经元死亡的重要形式。恰当时间窗内对神经元凋亡进行干预将是缺血、缺氧性脑病的有效治疗措施。

References

[1]  邹哲华, 陶陶, 徐坚, 等. 大鼠大脑皮层神经元缺氧后细胞凋亡情况的动态观察[J]. 第三军医大学学报,2012,34(24):2489-2492.
[2]  周帅,蒋理,程崇杰,等.载脂蛋白E对星形胶质细胞缺氧性损伤的保护作用[J].第三军医大学学报,2012,34(20):2067.  Zhou Shuai,Jiang Li,Cheng Chongjie,et al.Apolipoprotein E protects hypoxic injuried astrocytes in vitro[J].J Third Mil Med Univ,2012,34(24):2067. [2]生宝亮,徐刚,陈德伟,等.大鼠实验性高原肺水肿中T-AOC、MDA、SOD、CAT和IL-6的表达[J].第三军医大学学报,2012,34(23):2364.  Sheng Baoliang,Xu Gang,Chen Dewei,et al.T-AOC,MDA,SOD,CAT and IL-6 levels in rat pulmonary edema induced by hypobaric hypoxia[J].J Third Mil Med Univ,2012,34(24):2364. [3]魏勇,顾健腾,鲁开智,等.瑞芬太尼对肝细胞缺氧复氧损伤保护作用的机制研究[J].第三军医大学学报,2007,29(20):1976.  WEI Yong,GU Jian-teng,LU Kai-zhi,et al.Remifentanyl protects hepatocytes against anoxia-reoxygenation injury[J].J Third Mil Med Univ,2007,29(24):1976. [4]杨兆瑞,吴晴,陈嘉薇,等.HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达与临床病理及预后的关系[J].第三军医大学学报,2007,29(18):1755.  YANG Zhao-rui,WU Qing,CHEN Jia-wei,et al.Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma[J].J Third Mil Med Univ,2007,29(24):1755. [5]郑鸿燕,邰浩清,周春祥,等.蒺藜皂苷诱导SD新生大鼠海马神经干细胞分化的实验研究[J].第三军医大学学报,2007,29(18):1764.  ZHENG Hong-yan,TAI Hao-qing,ZHOU Chun-xiang,et al.Effects of total saponins of tribulus on the differentiation of rat neural hippocampus stem cells[J].J Third Mil Med Univ,2007,29(24):1764. [6]罗红,高文祥,高钰琪,等.茶多酚预防缺氧大鼠红细胞增多症的实验研究[J].第三军医大学学报,2007,29(14):1381.  LUO Hong,GAO Wen-xiang,GAO Yu-qi,et al.Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats[J].J Third Mil Med Univ,2007,29(24):1381. [7]刘茜,吴亚梅,徐玲,等.急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J].第三军医大学学报,2007,29(13):1311.  LIU Xi,WU Ya-mei,XU Ling,et al.Influence of hypoxia on leptin expression in C57BL/6J mice[J].J Third Mil Med Univ,2007,29(24):1311. [8]秦伟,阴正勤,翁传煌,等.大鼠视皮层两类神经元的NMDA及GABAA受体介导的突触后电流电学特性研究[J].第三军医大学学报,2008,30(08):714.  QIN Wei,YIN Zheng-qin,WENG Chuan-huang,et al.Properties of the postsynaptic currents mediated by NMDA receptors or GABAA receptors recorded in the pyramidal or granular neurons of rat visual cortex[J].J Third Mil Med Univ,2008,30(24):714. [9]王国毅,陶国才,易斌,等.咪达唑仑对幼龄大鼠大脑神经元caspase-3活化的影响[J].第三军医大学学报,2008,30(04):337.  WANG Guo-yi,TAO Guo-cai,YI Bin,et al.Effect of Midazolam on caspase-3 activation of cerebral neurons in 7-day-old rats[J].J Third Mil Med Univ,2008,30(24):337. [10]张钢,高钰琪,刘福玉.缺氧对大鼠白细胞粘弹性的影响[J].第三军医大学学报,2008,30(01):46.  ZHANG Gang,GAO Yu-qi,LIU Fu-yu.Effects of hypoxia on viscoelastic properties of polymorphonuclear leukocyte of rats[J].J Third Mil Med Univ,2008,30(24):46. [11]李江涛,胡胜利,杜鹏,等.缺氧条件下大鼠神经元白细胞介素-1受体相关激酶-1的表达变化[J].第三军医大学学报,2010,32(08):794.  Li Jiangtao,Hu Shengli,Du Peng,et al.Hypoxia induces expression of interleukin-1 receptor-associated kinases-1 in rat neurons[J].J Third Mil Med Univ,2010,32(24):794.

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