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E-cadherin在肝癌组织中的表达及其对肝癌患者预后的影响

, PP. 2301-2303

Keywords: 肝癌,肿瘤标志物,E-cadherin,预后

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Abstract:

目的探讨E-cadherin在肝癌组织中的表达及其在肝癌预后评判方面的价值。方法收集南方医科大学中西医结合医院外二科2005年1月至2009年6月接受肝脏手术的肝癌患者79例,男性69例,女性10例,年龄23~78(51.69±12.84)岁。用Westernblot方法检测5对肝癌及癌旁组织中E-cadherin的蛋白水平。免疫组化技术检测79例肝癌组织中E-cadherin的蛋白表达水平,分析E-cadherin表达与组织学分级的相关性,并通过Kaplan-Meier方法和Logrank检验比较不同E-cadherin表达水平患者的预后。结果在5对肝癌及癌旁组织中,有3例患者肝癌组织E-cadherin低表达。79例肝癌中有64例存在E-cadherin低表达,且肝癌组织中E-cadherin表达明显低于正常肝组织(P<0.01)。肝癌中E-cadherin低表达与高的组织学分级相关(P=0.028),且E-cadherin低表达组预后较中/高表达组差(P=0.0409)。结论肝癌组织中E-cadherin低表达提示患者不良预后。

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