全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

预缺氧对大鼠低压缺氧性脑损伤保护作用的实验研究

, PP. 2113-2115

Keywords: 缺氧,预缺氧,海马,学习记忆能力,凋亡

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探讨预缺氧对严重低压缺氧引起大鼠海马神经细胞损伤及学习记忆能力降低的保护作用。方法①Wistar大鼠分为对照组、单纯缺氧组、预缺氧复合缺氧组。光镜和电镜观察大鼠海马CA1区神经元形态变化;TUNEL法检测海马CA1区神经元凋亡。②单纯缺氧组和预缺氧复合缺氧组大鼠进行穿梭箱主动回避训练,随后进行低压缺氧,观察大鼠学习记忆能力的改变。结果预缺氧复合缺氧组大鼠CA1区神经元病理改变较轻,神经元凋亡显著低于单纯缺氧组(P<0.05);预缺氧复合缺氧组大鼠在严重缺氧后受电击次数和主动逃避时间的增加显著低于单纯缺氧组(P<0.05)。结论缺氧引起大鼠海马CA1区神经元凋亡等病理改变,并导致学习记忆能力降低;预缺氧对海马CA1区神经元的缺氧性损伤具有保护作用,并能有效减轻严重缺氧所导致的学习记忆能力下降。

References

[1]  陈建,黄缄,高钰琪,等.? 预缺氧对大鼠低压缺氧性脑损伤保护作用的实验研究[J].?第三军医大学学报, 2007, 29(22):2113-2115.?
[2]  周帅,蒋理,程崇杰,等.载脂蛋白E对星形胶质细胞缺氧性损伤的保护作用[J].第三军医大学学报,2012,34(20):2067.  Zhou Shuai,Jiang Li,Cheng Chongjie,et al.Apolipoprotein E protects hypoxic injuried astrocytes in vitro[J].J Third Mil Med Univ,2012,34(22):2067. [2]生宝亮,徐刚,陈德伟,等.大鼠实验性高原肺水肿中T-AOC、MDA、SOD、CAT和IL-6的表达[J].第三军医大学学报,2012,34(23):2364.  Sheng Baoliang,Xu Gang,Chen Dewei,et al.T-AOC,MDA,SOD,CAT and IL-6 levels in rat pulmonary edema induced by hypobaric hypoxia[J].J Third Mil Med Univ,2012,34(22):2364. [3]邹哲华,陶陶,徐坚,等.大鼠大脑皮层神经元缺氧后细胞凋亡情况的动态观察[J].第三军医大学学报,2012,34(24):2489.  Zou Zhehua,Tao Tao,Xu Jian,et al.Dynamic changes of apoptosis in rat cerebral cortex neurons after hypoxia[J].J Third Mil Med Univ,2012,34(22):2489. [4]魏勇,顾健腾,鲁开智,等.瑞芬太尼对肝细胞缺氧复氧损伤保护作用的机制研究[J].第三军医大学学报,2007,29(20):1976.  WEI Yong,GU Jian-teng,LU Kai-zhi,et al.Remifentanyl protects hepatocytes against anoxia-reoxygenation injury[J].J Third Mil Med Univ,2007,29(22):1976. [5]杨兆瑞,吴晴,陈嘉薇,等.HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达与临床病理及预后的关系[J].第三军医大学学报,2007,29(18):1755.  YANG Zhao-rui,WU Qing,CHEN Jia-wei,et al.Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma[J].J Third Mil Med Univ,2007,29(22):1755. [6]罗红,高文祥,高钰琪,等.茶多酚预防缺氧大鼠红细胞增多症的实验研究[J].第三军医大学学报,2007,29(14):1381.  LUO Hong,GAO Wen-xiang,GAO Yu-qi,et al.Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats[J].J Third Mil Med Univ,2007,29(22):1381. [7]刘茜,吴亚梅,徐玲,等.急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J].第三军医大学学报,2007,29(13):1311.  LIU Xi,WU Ya-mei,XU Ling,et al.Influence of hypoxia on leptin expression in C57BL/6J mice[J].J Third Mil Med Univ,2007,29(22):1311. [8]张钢,高钰琪,刘福玉.缺氧对大鼠白细胞粘弹性的影响[J].第三军医大学学报,2008,30(01):46.  ZHANG Gang,GAO Yu-qi,LIU Fu-yu.Effects of hypoxia on viscoelastic properties of polymorphonuclear leukocyte of rats[J].J Third Mil Med Univ,2008,30(22):46. [9]吴喜贵,赵延东,阮怀珍.缺氧对大鼠皮层、海马NMDA受体NR1亚单位磷酸化的影响[J].第三军医大学学报,2007,29(18):1742.  WU Xi-gui,ZHAO Yan-dong,RUAN Huai-zhen.Effect of hypoxia on NR1 subunit of NMDA receptor in rat cortex and hippocampus[J].J Third Mil Med Univ,2007,29(22):1742. [10]何秀娟,许蜀闽,张涛,等.缺氧时肺动脉平滑肌细胞膜电位、细胞质及线粒体Ca2+的动态变化[J].第三军医大学学报,2007,29(15):1477.  HE Xiu-juan,XU Shu-min,ZHANG Tao,et al.Dynamic changes of membrane potentials, cytoplasmic and mitochondrial Ca2+ in cultured pulmonary artery smooth muscle cells exposed to hypoxia[J].J Third Mil Med Univ,2007,29(22):1477.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133