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血管抑素下调人舌鳞癌细胞血管内皮生长因子的表达

, PP. 1557-1560

Keywords: 血管抑素,血管内皮生长因子,舌鳞癌

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Abstract:

目的探讨血管抑素(angiostatin,AS)对人舌鳞癌细胞血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)表达的影响。方法将Tca8113人舌鳞癌细胞移植到18只裸鼠皮下,用随机数字表法将裸鼠分成3组(每组6只)。PBS组:注射PBS;AS(250ng)组:注射250ng纯化AS;AS(30μg)组:注射30μg纯化AS,腹腔注射,2次/d,同时测量肿瘤的大小,2次/周。21d后处死小鼠,将取出的每个肿瘤2等分,一半用免疫组织化学检测VEGF及其两个受体(VEGFR1、VEGFR2)和CD34,用TUNEL法检测肿瘤细胞的凋亡;另一半用半定量RT-PCR检测VEGF、VEGFR1和VEGFR2的mRNA表达。结果AS(250ng)组和AS(30μg)组中,细胞凋亡指数(AI)明显增加(P<0.05);而肿瘤体积、微血管密度(MVD,用CD34抗体标记并用来评价肿瘤血管生成)及VEGF、VEGFR1和VEGFR2在蛋白质和mRNA的水平表达,都有明显降低(P<0.05),且AS(30μg)组更为显著。结论AS下调人舌鳞癌细胞VEGF的表达且呈剂量依赖性。

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