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不同浓度NO对缺氧心肌细胞损害的影响

, PP. 1017-1019

Keywords: 缺氧,NO,S-亚硝基谷胱甘肽,保护作用

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Abstract:

目的利用外源性一氧化氮(nitricoxide,NO)供体S-亚硝基谷胱甘肽(S-nitrosoglutathione,GSNO)对比观察不同浓度NO对缺氧心肌细胞活力的影响。方法培养4~6d心肌细胞分为常氧组(N)、缺氧组(H)和缺氧+GSNO组(H+G);H+G组依照加入GSNO浓度的不同又分为3组:缺氧+GSNO30μmol/L组(H+G30)、缺氧+GSNO200μmol/L组(H+G200)、缺氧+GSNO4000μmol/L组(H+G4000)。分别观察其对缺氧(1%O2、5%CO2和94%N2)4h心肌细胞损害的影响。结果缺氧引起培养心肌细胞上清LDH活性增加,细胞存活率(MTT法)降低,H+G30组和H+G4000组损伤加重,H+G200组损伤减轻。结论一定浓度范围内的NO具有细胞保护效应。

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