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间充质干细胞成骨诱导后免疫原性的研究

, PP. 663-665

Keywords: 间充质干细胞,诱导,混合淋巴培养,免疫原性

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Abstract:

目的研究间充质干细胞(mesenchymalstemcells,MSCs)成骨诱导后的免疫原性。方法小型猪骨髓MSCs体外分离培养,成骨诱导1、7、14、21d后,行流式检测MHC-Ⅱ,单向混合淋巴细胞培养(mixedlymphocyteculture,MLC)测定刺激指数(stimulationindex,SI),并测定混和培养上清IL-2和IL-10的变化。结果MSCs诱导后1、7、14、21d均未检测到MHC-Ⅱ表达,MLC未测到细胞明显增殖,上清IL-2和IL-10无显著变化(P>0.05)。结论MSCs体外成骨诱导后的免疫原性低。

References

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