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SDF-1对内皮祖细胞增殖迁移的影响及AMD3100对其的干预

, PP. 475-478

Keywords: 内皮祖细胞,基质细胞衍生因子-,AMD,增殖,迁移

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Abstract:

目的探讨基质细胞衍生因子-1(stromalcellderivedfactor-1,SDF-1)对小鼠骨髓源性内皮祖细胞(endothelialprogenitorcells,EPCs)增殖迁移的影响及AMD3100对其的干预效应。方法分别用不同浓度的SDF-1α刺激EPCs,观察SDF-1α的促增殖效应再用不同浓度的AMD3100干预5ng/mlSDF-1α的促增殖效应及单用AMD3100与EPCs孵育,观察AMD3100对EPCs增殖的影响。MTT比色法检测EPCs的增殖情况。用1、10ng/mlSDF-1α诱导EPCs迁移,或先用10ng/mlAMD3100与EPCs孵育,再做SDF-1α诱导的/无SDF-1α诱导的迁移实验。用改良的Boyden小室测定EPCs迁移能力。结果SDF-1α剂量依赖性增强EPCs增殖能力,10ng/mlAMD3100即完全阻断5ng/mlSDF-1α的促进EPCs增殖效应,单用AMD3100孵育可抑制EPCs增殖,与阴性对照组比较差异显著(P<0.01);单用AMD3100孵育抑制EPCs迁移,与阴性对照组比较差异显著(P<0.01)。结论SDF-1α可增强EPCs增殖迁移能力,AMD3100可完全阻断其促增殖和诱导迁移效应,单用AMD3100抑制EPCs增殖迁移。

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