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大鼠动脉粥样硬化病变组织致炎-抗炎因子抗体芯片分析

, PP. 210-212

Keywords: 动脉粥样硬化,细胞因子,抗体芯片

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Abstract:

目的探讨动脉粥样硬化初始时病变部位细胞因子的变化。方法腹腔注射酵母多醣诱发炎症叠加卵清蛋白激发免疫反应的方法,在高脂饮食的基础上诱导大鼠动脉粥样硬化。电镜检测主动脉壁泡沫细胞,抗体芯片试剂盒RayBio?RatCytokineAntibodyArray1.1检测主动脉壁细胞因子。结果电镜下模型组见单核细胞穿过内膜层迁移至增宽的内皮下间隙并在内膜下聚集,形成血源性的单核细胞泡沫化,即典型的AS病变。抗体芯片显示除Fractalkine、IL-6外所有致炎因子均呈升高趋势,所有抗炎因子均呈微弱降低趋势。结论炎症免疫刺激是AS发生的诱因之一,众多致炎因子与抗炎因子之间的平衡被打破是导致AS的重要原因。

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