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三氧化二砷诱导人卵巢癌细胞凋亡对端粒酶活性的影响

, PP. 62-64

Keywords: 三氧化二砷,人卵巢癌细胞,细胞凋亡,端粒酶活性

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Abstract:

目的探讨As2O3诱导细胞凋亡时对其端粒酶活性的影响及其作用机制。方法采用光镜、电镜,PCR-ELISA,RT-PCR等技术,检测细胞凋亡,端粒酶活性及其催化亚单位的表达。结果As2O3可诱导卵巢癌细胞凋亡,但存在作用浓度,细胞株类型差异性;端粒酶活性随药物作用时间和浓度的增加而明显减弱,同时伴随hTERTmRNA表达水平的下降。结论端粒酶活性和hTERTmRNA表达在As2O3诱导SKOV3、3AO细胞凋亡过程中共同发挥作用,两者有密切关系,是诱导细胞凋亡的分子机制之一。

References

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