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Tiam1基因沉默降低结肠癌细胞VEGF-C/-D的表达?

, PP. 1607-1610

Keywords: ,结肠癌,Tiam,VEGF-C/-D?

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Abstract:

目的探讨T淋巴瘤侵袭转移诱导因子1(Tiam1)的表达与结肠癌淋巴管生成的关系。方法将实验细胞分为3组,分别为未干扰组(HCT116)、空质粒载体对照组(HCT116/CN)和干扰组(HCT116/siRNA-Tiam1)。应用siRNA使Tiam1基因表达下调,通过RT-PCR检测Tiam1mRNA表达抑制率,并用RT-PCR和Westernblot方法检测Tiam1基因干扰前后VEGF-C/-DmRNA和蛋白的表达情况。结果通过筛选后稳定表达的情况下,siRNA组的Tiam1、VEGF-C/-DmRNA和蛋白的表达明显低于未干扰组。结论Tiam1参与了VEGF-C/-D表达的调节,推测Tiam1可能通过诱导VEGF-C/-D的表达影响结肠癌淋巴管的生成。Tiam1可作为结肠癌淋巴转移过程中一个有价值的指标。

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