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阿托伐他汀对代谢综合征腹内脂肪及其肾损害的影响

, PP. 1478-1480

Keywords: 代谢综合征,阿托伐他汀,腹部脂肪,微量白蛋白

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Abstract:

目的观察阿托伐他汀对代谢综合征(metabolicsyndrome,MS)的腹内脂肪的影响及其与肾损害的关系。方法2004-2006年曾在我科住院并诊断为MS的患者44例,按随机数字表法分成2组,在严格控制血压血糖的基础上,治疗组加用阿托伐他汀10mg,1次/d;对照组不予任何调脂药,观察两组血压、血糖、体质量、腹壁、腹内脂肪厚度及尿微量白蛋白(MAU)在12周治疗前后的变化。结果治疗组12周后患者的腹内脂肪厚度显著减少[非ACEI/ARB治疗:(41.76±3.61)mmvs(33.23±2.47)mm;ACEI/ARB治疗:(42.86±3.49)mmvs(30.49±2.87)mm,P<0.01],尿微量白蛋白明显下降[非ACEI/ARB治疗:(77.59±20.90)mg/24hvs(35.20±14.45)mg/24h;ACEI/ARB治疗:(78.39±19.78)mg/24hvs(32.91±13.87)mg/24h,P<0.05]。多因素分析显示对MAU增多有影响的危险因素依次为空腹血糖、甘油三酯、收缩压、年龄、腹内脂肪。结论阿托伐他汀可减少MS的腹内脂肪厚度,并对肾损害有保护作用,可能与减少内脏脂肪有关。

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