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B型利钠肽对小鼠腹腔巨噬细胞MCP-1蛋白表达的双向调节作用

, PP. 1452-1455

Keywords: B型利钠肽,巨噬细胞,单核细胞趋化蛋白-,肿瘤坏死因子-α,小鼠

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Abstract:

目的观察B型利钠肽(Btypenatriureticpeptides,BNP)在小鼠腹腔巨噬细胞内介导单核细胞趋化蛋白-1(monocytechemoattractantprotein-1,MCP-1)蛋白的表达,探讨BNP在小鼠腹腔巨噬细胞中调节炎症反应的作用。方法原代培养小鼠腹腔巨噬细胞,分别予不同剂量的BNP、BNP+GC-A受体抑制剂(HS-142-1)、BNP+肿瘤坏死因子-α(TNF-α)+HS-142-1预处理细胞,设立空白对照组。提取培养细胞蛋白,采用Westernblot法检测细胞内MCP-1蛋白表达。结果在小鼠巨噬细胞内BNP能够促进MCP-1蛋白表达,该作用可被BNP抑制剂HS-142-1所抑制;且TNF-α在巨噬细胞中促进MCP-1分泌的作用可以被BNP抑制。结论BNP能够促进巨噬细胞释放MCP-1,促进炎症反应的发生;同时BNP能够抑制TNF-α促进MCP-1蛋白分泌的作用,提示BNP具有炎症反应的双向调节作用。

References

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