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慢性肾病患者肾小管上皮细胞内质网应激与细胞凋亡的关系

, PP. 1010-1013

Keywords: 慢性肾病,内质网应激,细胞凋亡

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Abstract:

目的探讨慢性肾病(chronickidneydisease,CKD)患者蛋白尿诱导肾小管上皮细胞内质网应激与细胞凋亡的关系。方法应用免疫组织化学技术检测CKD患者肾小管上皮细胞中内质网应激标志蛋白氧调节蛋白150(cells-oxygen-regulatedprotein150,ORP150)和糖调节蛋白78(glucose-regulatedprotein78,GRP78)的表达;TUNEL法检测细胞凋亡。对各指标与CKD患者24h尿蛋白量进行相关性分析。结果CKD患者肾小管上皮细胞细胞质中ORP150、GRP78的表达较正常对照组显著增强(P<0.01),且轻、中、重度蛋白尿3组各组间亦均有显著性差异(P<0.01),并与尿蛋白水平呈正相关(r=0.695,r=0.76,P<0.01);各组小管上皮细胞凋亡系数(apoptosisindex,AI)均亦有显著性差异(P<0.01),并与尿蛋白水平呈正相关性(r=0.835,P<0.01)。结论CKD患者肾小管上皮细胞有内质网应激与凋亡的发生,并且其强度与蛋白尿水平呈正相关关系。内质网应激可能是大量蛋白尿引起小管上皮细胞凋亡的重要环节。

References

[1]  吴小玮,何娅妮,丁涵露,等. 慢性肾病患者肾小管上皮细胞内质网应激与细胞凋亡的关系[J].第三军医大学学报,2008,30(11):1010-1013?
[2]  牟歌,王晓敏,熊吉,等.PACS-2在非酒精性脂肪性肝病动态变化及意义[J].第三军医大学学报,2013,35(07):609.  Mu Ge,Wang Xiaomin,Xiong Ji,et al.Dynamic expression and significance of PACS-2 in non-alcoholic fatty liver disease[J].J Third Mil Med Univ,2013,35(11):609. [2]房殿亮,宁波,沈薇,等.干扰SREBP-1c对内质网应激状态下L02和HepG2肝细胞脂质沉积的影响[J].第三军医大学学报,2013,35(06):513.  Fang Dianliang,Ning Bo,Shen Wei,et al.SREBP-1c gene interference decreases lipid accumulation in L02 and HepG2 hepatocytes under endoplasmic reticulum stress[J].J Third Mil Med Univ,2013,35(11):513. [3]姚凤华,何娅妮,詹俊,等.内质网应激在急性缺血性大鼠肾损伤中的作用[J].第三军医大学学报,2009,31(11):1002.  YAO Feng-hua,HE Ya-ni,ZHAN Jun,et al.Role of endoplasmic reticulum stress in acute ischemic renal injury in rats[J].J Third Mil Med Univ,2009,31(11):1002. [4]曹洁,杨朝霞,沈薇,等.内质网应激在软脂酸钠诱导的脂肪变性L02肝细胞凋亡中的作用[J].第三军医大学学报,2011,33(18):1935.  Cao Jie,Yang Zhaoxia,Shen Wei,et al.Role of endoplasmic reticulum stress in palmitate sodium-induced apoptosis in steatotic L02 hepatocytes[J].J Third Mil Med Univ,2011,33(11):1935. [5]周洪文,甘华,杜晓刚,等.连续性血液滤过对多脏器功能衰竭患者血清诱导的血管内皮细胞凋亡及内质网应激的影响[J].第三军医大学学报,2010,32(08):805.  Zhou Hongwen,Gan Hua,Du Xiaogang,et al.Impact of continuous veno-venous hemofiltration on endoplasmic reticulum stress and apoptosis of HUVEC cells induced by serum of patients with multiple organ dysfunction syndrome[J].J Third Mil Med Univ,2010,32(11):805. [6]赵鹏,史忠,周坤,等.颈交感干离断对大鼠脑缺血再灌注损伤内质网应激相关因子的影响[J].第三军医大学学报,2010,32(22):2361.  Zhao Peng,Shi Zhong,Zhou Kun,et al.Effects of transection of cervical sympathetic trunk on endoplasmic reticulum stress related factors in rats after focal cerebral ischemia reperfusion injury[J].J Third Mil Med Univ,2010,32(11):2361. [7]闵敏,陈东风,王军,等.葡萄糖调节蛋白78在大鼠非酒精性脂肪性肝炎中的表达及意义[J].第三军医大学学报,2009,31(01):79.  MIN Min,CHEN Dong-feng,WANG Jun,et al.Expression and significance of glucose regulated protein GRP78 in nonalcoholic steatohepatitis of rats[J].J Third Mil Med Univ,2009,31(11):79. [8]童玉娜,杨聚荣,张建国,等.内质网应激在大鼠肾小管上皮细胞缺氧复氧损伤炎症反应中的作用[J].第三军医大学学报,2011,33(05):455.  Tong Yuna,Yang Jurong,Zhang Jianguo,et al.Role of endoplasmic reticulum stress in hypoxia/reoxygenation-induced inflammation in rat renal tubular epithelial cells[J].J Third Mil Med Univ,2011,33(11):455. [9]熊吉,王军,樊丽琳,等.Sigma-1受体在非酒精性脂肪性肝病中的表达及意义[J].第三军医大学学报,2011,33(08):800.  Xiong Ji,Wang Jun,Fan Lilin,et al.Expression and significance of Sigma-1 receptor in non-alcoholic fatty liver disease[J].J Third Mil Med Univ,2011,33(11):800. [10]胡畔,李涛,丁晓莉,等.GRP78和CHOP蛋白表达增加与脓毒性休克大鼠肺血管通透性改变的关系[J].第三军医大学学报,2013,35(09):854.  Hu Pan,Li Tao,Ding Xiaoli,et al.Relationship of GRP78 and CHOP expression with pulmonary vascular permeability in rat model of endoplasmic reticulum stress during septic shock[J].J Third Mil Med Univ,2013,35(11):854.

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