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外源性Wnt5a激活K562细胞非经典Wnt5a/Ca2+信号途径研究

, PP. 924-927

Keywords: Wnta,K细胞,Ca+,β-catenin,cyclinD

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Abstract:

目的观察外源性Wat5a对K562细胞非经典Wnt5a/Ca2+途径的影响,进一步研究外源性Wnt5a诱导K562细胞的分化机制。方法激光共聚焦显微镜观察Ca2+内流的变化,以RT-PCR及免疫组化检测β-catenin的表达变化,以Westernblot检测cyclinD1的表达变化。结果外源性Wnt5a能明显促进K562细胞Ca2+内流,显著下调cyclinD1表达,且能下调K562细胞β-catenin表达,但β-catenin表达下调无统计学意义。结论外源性Wnt5a能激活K562细胞非经典Wnt5a/Ca2+途径,外源性Wnt5a诱导K562细胞分化机制可能与此相关。

References

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