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SOCS3对肺腺癌细胞株A549迁移和侵袭能力的影响

, PP. 588-591

Keywords: 肺腺癌,侵袭,转移,SOCS

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Abstract:

目的观察细胞因子信号负调控因子3(suppressorsofcytokinesignaling,SOCS3)对人肺腺癌细胞株A549迁移和侵袭能力的影响,并初步探讨其机制。方法建立SOCS3稳定表达细胞株;BoydenChamber分析法测定细胞的迁移和侵袭能力;半定量RT-PCR检测细胞基质金属蛋白酶(matrixmetalloproteinases,MMPs)2,9mRNA表达;明胶酶谱分析法测定MMP2,9蛋白活性水平。结果SOCS3稳定表达株细胞迁移和侵袭能力显著下降(P<0.05);半定量RT-PCR和明胶酶谱分析结果显示SOCS3可显著抑制MMP2,9表达和活性(P<0.05)。结论SOCS3能通过抑制MMP2,9表达和活性明显降低A549的体外迁移和侵袭能力。

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