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脂联素基因Gly15Gly多态性与糖尿病大血管病变的关系

, PP. 536-538

Keywords: 脂联素,基因多态性,糖尿病,大血管病变

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Abstract:

摘要:目的探讨脂联素基因Gly15Gly多态性与糖尿病早期大血管病变发生的关系。方法运用多聚酶链式反应-限制性片段长度基因多态性(PCR-RFLP法)分析方法,对56例伴大血管病变和120例无大血管病变的2型糖尿病患者脂联素基因Gly15Gly多态性位点进行基因分型。结果大血管病变组GG基因型频率(25.0%)显著高于无血管病变组(6.2%),G等位基因频率显著升高(P<0.05);GG基因型血浆脂联素水平显著低于TT和TG基因型。结论脂联素基因Gly15Gly多态性与糖尿病大血管并发症的发生有关,脂联素基因+45位点GG基因型是2型糖尿病大血管并发症的易感基因型。

References

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