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亚临床甲状腺功能减退症患者血浆对氧磷酯酶1活性与氧化应激状态的评价

, PP. 2106-2108

Keywords: 氧化应激,对氧磷酯酶,亚临床甲状腺功能减退症

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Abstract:

目的评价亚临床甲状腺功能减退症(subclinicalhypothyroidism,SCH)患者血浆对氧磷酯酶1(paraoxonase1,PON1)活性及氧化应激状态,以及PON1与氧化应激的关系。方法测定56例亚临床甲减患者与48例年龄相匹配的健康体检者血浆PON1活性、血脂水平、氧化型低密度脂蛋白(ox-LDL)含量、丙二醛(MDA)水平及超氧化物歧化酶(SOD)活力,并进行相关性分析。结果亚临床甲减患者血浆PON1[(142±56)kU/L]和SOD[(83.2±26.1)U/ml]明显低于对照组PON1[(167±60)kU/L,P<0.01]和SOD[(93.1±28.2)U/ml,P<0.05];MDA[(14.10±3.01)μmol/L]和ox-LDL[(596.2±68.1)μg/L]的水平明显高于健康对照组MDA[(10.25±3.34)μmol/L,P<0.01]和ox-LDL[(467.2±60.1)μg/L,P<0.01]。亚临床甲减患者血浆PON1活性与SOD呈显著正相关(r=0.302,P<0.05),与ox-LDL(r=-0.398,P<0.01)及MDA(r=-0.401,P<0.01)呈显著负相关。结论亚临床甲减患者活性氧(ROS)产生的增加导致氧化环境的改变,可能使血浆PON1活性显著降低。PON1可能通过降低抗氧化能力机制参与了亚临床甲状腺功能减退症的病理、生理过程。?

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