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脂联素对TNF-α诱导的人脐静脉内皮细胞粘附因子mRNA表达的影响

, PP. 1876-1880

Keywords: 脂联素,黏附因子,人脐静脉内皮细胞,动脉硬化

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Abstract:

目的探讨脂联素对肿瘤坏死因子(TNF-α)引起的人脐静脉内皮细胞(humanumbilicalveinendothelialcells,HUVCEs)分泌黏附因子的影响。方法体外培养人脐静脉内皮细胞(HUVECs),随机分为对照组、TNF-α刺激组和脂联素干扰组.用PCR方法检测脂联素对人脐静脉内皮细胞VCAM-1,ICAM-1和E-selectinmRNA表达的影响。结果HUVECs经TNF-α刺激6h后其VCAM-1、ICAM-1和E-selectinmRNA表达较对照组相比明显增强(P<0.05);当HUVECs在TNF-α刺激之前首先与不同浓度的脂联素共同孵育一段时间后,其VCAM-1、ICAM-1和E-selectinmRNA表达与单纯给予TNF-α刺激相比明显减弱(P<0.05),并呈现剂量依赖性。结论脂联素可以通过抑制血管内皮细胞黏附因子的表达水平来调节血管内皮细胞的炎症反应,从而发挥其抗炎,抗动脉粥样硬化的作用。

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