全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

牵张负荷对大鼠膀胱Cajal间质细胞超微形态及c-kit基因表达影响

, PP. 1284-1286

Keywords: 牵张负荷,ICCs细胞,c-kit

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的通过研究膀胱Cajal间质细胞(Interstitialcellsofcajal,ICCs)超微形态及c-kit基因水平变化,阐明牵张负荷对膀胱Cajal细胞兴奋性的调控作用。方法结扎膀胱颈,构建大鼠膀胱出口部分梗阻致逼尿肌过度活动模型,通过扫描电镜方法观察牵张负荷条件下逼尿肌过度活动组与正常对照组膀胱ICCs细胞超微形态变化,观察牵张负荷条件下逼尿肌稳定组和逼尿肌过度活动组与正常对照组膀胱ICCs细胞酪氨酸激酶受体(c-kit)在基因水平表达差异。结果逼尿肌过度活动组ICCs细胞形态和c-kit基因水平表达量较正常对照组有明显改变(P<0.01)。结论牵张负荷对ICCs细胞有调控作用,可能的作用机制在于改变ICCs细胞形态及上调c-kit表达。

References

[1]  路扬, 李龙坤, 王永权.牵张负荷对大鼠膀胱Cajal间质细胞超微形态及c-kit基因表达影响[J]. 第三军医大学学报,2009,31(13):1284-1286.
[2]  李龙坤,宋波.膀胱ICCs细胞与逼尿肌兴奋性关系研究现状[J].第三军医大学学报,2008,30(07):555. [2]封建立,方强,丁砺蠡,等.ICCs细胞在正常大鼠膀胱中的分布及对逼尿肌收缩的影响[J].第三军医大学学报,2008,30(07):559.  FENG Jianli,FANG Qiang,DING Li-li,et al.Distribution of interstitial cells of Cajal in normal rat bladder and its effect on detrusor contraction[J].J Third Mil Med Univ,2008,30(13):559. [3]方强,杨景,潘进洪,等.P2X嘌呤受体在大鼠膀胱ICCs细胞中的表达[J].第三军医大学学报,2008,30(07):564.  FANG Qiang,YANG Jing,PAN Jin-hong FENG Jian-li,et al.Expression of P2X purinoceptor in interstitial cells of Cajal in rat bladder[J].J Third Mil Med Univ,2008,30(13):564. [4]路扬,李龙坤,王永权.牵张负荷对大鼠膀胱ICCs细胞数量及c-kit表达的影响[J].第三军医大学学报,2008,30(07):570.  LU Yang,LI Long-kun,WANG Yong-quan.Effects of stretch load on quantity and c-kit expression of rat bladder interstitial cells of Cajal[J].J Third Mil Med Univ,2008,30(13):570. [5]王永权,方强,路扬,等.牵张负荷对豚鼠膀胱ICCs细胞内钙波的影响[J].第三军医大学学报,2008,30(07):574.  WANG Yong-quan,FANG Qiang,LU-Yang,et al.Effect of stretch load on calcium wave of interstitial cells of Cajal in guinea pig bladder[J].J Third Mil Med Univ,2008,30(13):574. [6]丁砺蠡,王永权,方强,等.大鼠不稳定膀胱中ICCs细胞中HCN蛋白表达的变化[J].第三军医大学学报,2008,30(07):578.  DING Li-li,WANG Yong-quan,FANG Qiang,et al.Variation of HCN protein expression in interstitial cells of Cajal from rat with detrusor instability[J].J Third Mil Med Univ,2008,30(13):578. [7]封建立,李龙坤,杨景,等.不稳定逼尿肌中ICCs细胞与逼尿肌收缩的关系[J].第三军医大学学报,2008,30(10):894.  FENG Jian-li,LI Long-kun,YANG Jing,et al.Relationship between interstitial cells of Cajal cells and contraction of detrusor myocyte in rats[J].J Third Mil Med Univ,2008,30(13):894. [8]郑霁,贾卓敏,张永革,等.胞外钙及胞内钙库钙在膀胱ICCs细胞自发性钙瞬变中的作用[J].第三军医大学学报,2009,31(10):918.  ZHENG Qi,JIA Zhuo-min,ZHANG Yong-ge,et al.Role of Ca2+ entry and Ca2+ store in ICCs’ spontaneous Ca2+ transients in rat bladder[J].J Third Mil Med Univ,2009,31(13):918. [9]邓建平,沈文浩,张永革,等.ICCs细胞在糖尿病大鼠膀胱中的密度分布及其对糖尿病膀胱功能的影响[J].第三军医大学学报,2010,32(01):23.  Deng Jianping,Shen Wenhao,Zhang Yongge,et al.Density distribution of interstitial cells of Cajal in bladder of diabetic cystopathy rats and its role in bladder function[J].J Third Mil Med Univ,2010,32(13):23.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133