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白藜芦醇抑制A549人肺腺癌细胞增殖与IGF-ⅠR的关系

, PP. 2567-2570

Keywords: 白藜芦醇,胰岛素样生长因子-,胰岛素样生长因子-受体,人肺腺癌细胞A

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Abstract:

目的探讨白藜芦醇对人肺腺癌A549细胞增殖的抑制效应及其与IGF-ⅠR的关系。方法以人肺腺癌A549细胞株为研究对象,采用MTT方法测定细胞增殖,用RT-PCR与免疫印迹方法测定IGF-Ⅰ受体mRNA与蛋白表达水平。结果2.5~15nmol/LIGF-Ⅰ可显著促进A549细胞增殖(P<0.05),给予12.5、25.0、50μmol/L白藜芦醇对A549细胞增殖具有明显抑制作用(P<0.05)。白藜芦醇(6.25~50μmol/L)与10nmol/LIGF-Ⅰ共作用于A549细胞,均可抑制IGF-Ⅰ的促A549细胞增殖作用,其中尤以25、50μmol/L白藜芦醇的抑制增殖作用显著(P<0.05),白藜芦醇可有效降低IGF-ⅠRmRNA与蛋白表达。结论白藜芦醇可通过降低IGF-ⅠRmRNA与蛋白表达有效抑制IGF-Ⅰ介导的A549肺癌细胞增殖。

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