全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

PTEN、p38MAPK在人脑胶质瘤中的表达及意义

, PP. 2310-2312

Keywords: 胶质瘤,PTEN,pMAKP,免疫组化

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的初探PTEN和p38MAKP在人脑胶质瘤中的表达及意义。方法采用免疫组织化学S-P法检测43例低级别胶质瘤(Ⅰ和Ⅱ级)和21例高级别胶质瘤(Ⅲ级和Ⅳ级)PTEN和p38MAKP的表达情况,并分析二者之间的关系。结果PTEN和p38MAKP在不同级别胶质瘤中的表达不同,随着病理级别的升高,PTEN表达均逐渐减弱[Ⅰ级77.27%(17/22);Ⅱ级66.67%(14/21);Ⅲ级46.15%(6/13);Ⅳ级37.50%(3/8)],而p38MAKP表达均逐渐增强[Ⅰ级22.73%(5/22);Ⅱ级39.10%(8/21);Ⅲ级53.85%(7/13);Ⅳ级75.00%(6/8)],低级别胶质瘤组与高级别胶质瘤组比较,差异有统计学意义(P<0.05),且两者在人脑胶质瘤中的表达呈负相关(r=-0.411,P<0.05)。结论PTEN和p38MAKP蛋白的异常表达可能参与胶质瘤的恶性进展,检测二者蛋白的表达水平有助于评价胶质瘤的恶性程度和生物学行为。

References

[1]  陈松,程远,廖鹏,等.S100A9真核表达载体pEGFP-N3-S100A9的构建及其对U251细胞生长的影响[J].第三军医大学学报,2012,34(16):1596.  Chen Song,Cheng Yuan,Liao Peng,et al.Construction of S100A9 eukaryotic expression vector and its effect on proliferation of glioma cell line U251[J].J Third Mil Med Univ,2012,34(21):1596. [2]杨德辉,陈雪梅,何俊琳,等.hsa-miR-200a对HEC-1B人子宫内膜腺癌细胞系增殖与凋亡的影响[J].第三军医大学学报,2012,34(16):1608.  Yang Dehui,Chen Xuemei,He Junlin,et al.Effect of hsa-miR-200a on proliferation and apoptosis in human endometrium adenocarcinoma cell line HEC-1B[J].J Third Mil Med Univ,2012,34(21):1608. [3]姚一搏,许民辉,徐伦山,等.1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].第三军医大学学报,2012,34(18):1881.  Yao Yibo,Xu Minhui,Xu Lunshan,et al.Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance[J].J Third Mil Med Univ,2012,34(21):1881. [4]李长毅,张明川,梅同华,等.持续小剂量化疗对A549肺癌PTEN基因和凋亡的影响[J].第三军医大学学报,2007,29(18):1760.  LI Chang-yi,ZHANG Ming-chuan,MEI Tong-hua,et al.Low-dose metronomic chemotherapy upregulates PTEN and induces apoptosis of A549 pulmonary adenocarcinoma in athymic mice[J].J Third Mil Med Univ,2007,29(21):1760. [5]张萌,何宏涛,周烨,等.PPAR-γ和PTEN在肝细胞癌组织中的表达及预后价值[J].第三军医大学学报,2011,33(14):1476.  Zhang Meng,He Hongtao,Zhou Ye,et al.Expression and prognostic significance of PPAR-γ and PTEN protein in hepatocellular carcinoma[J].J Third Mil Med Univ,2011,33(21):1476. [6]杨雨晗,邓缅.PTEN基因调控口腔鳞癌细胞TCA-8113增殖及凋亡[J].第三军医大学学报,2011,33(14):1484.  Yang Yuhan,Deng Mian.PTEN gene expression inhibits proliferation and promotes apoptosis in human oral squamous carcinoma cell line TCA-8113[J].J Third Mil Med Univ,2011,33(21):1484. [7]姚声涛,唐文渊,郭川.LRIG1诱导人胶质瘤细胞凋亡与表皮生长因子受体基因关系[J].第三军医大学学报,2008,30(02):157.  YAO Sheng-tao,TANG Wen-yuan,GUO Chuan.Relationship between LRIG1 induced human glioma apoptosis and EGFR gene[J].J Third Mil Med Univ,2008,30(21):157. [8]王跃红,赵文清,李文玲,等.白介素-24抑制胶质瘤细胞生长的体内外实验研究[J].第三军医大学学报,2008,30(03):229.  WANG Yue-hong,ZHAO Wen-qing,LI Wen-ling,et al.Interleukin 24 suppresses the growth of malignant glioma cells in vitro and in vivo[J].J Third Mil Med Univ,2008,30(21):229. [9]陈晓玲,杨戎,贾咏存,等.PTEN基因在小鼠胚胎着床过程中作用的实验研究[J].第三军医大学学报,2007,29(21):2064.  CHEN Xiao-ling,YANG Rong,JIA Yong-cun,et al.PTEN gene expression in mouse endometria increases during embryo implantation[J].J Third Mil Med Univ,2007,29(21):2064. [10]张启川,张冬,廖翠薇,等.弥散加权成像对胶质瘤和脑膜瘤的诊断价值[J].第三军医大学学报,2008,30(16):1522.  ZHANG Qi-chuan,ZHANG Dong,LIAO Cui-wei,et al.Clinical application of DWI in diagnosis of glioma and meningioma[J].J Third Mil Med Univ,2008,30(21):1522.
[2]  辛艳超, 刘献志, 刘新, 等. PTEN、p38MAPK在人脑胶质瘤中的表达及意义[J].第三军医大学学报,2011,33(21):2310-2312.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133