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创伤后应激障碍患者静息状态下脑默认网络研究

, PP. 2271-2273

Keywords: 创伤后应激障碍,默认网络,功能磁共振成像,独立成分分析,静息状态

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Abstract:

目的探讨创伤后应激障碍(post-traumaticstressdisorders,PTSD)患者脑默认网络结构的变化。方法采用静息态功能磁共振成像技术,采集9例临床确诊PTSD患者和10名正常自愿者静息态脑功能数据,并运用独立成分分析方法(ICA)分离出每例受试者的脑默认网络,将其结果进行组内分析和组间分析。结果PTSD患者的脑默认网络左侧前内侧额叶和后扣带回区域功能连接度下降,而楔前叶区域功能连接显著增强。结论在静息状态下PTSD患者的脑默认网络连接发生改变,这为PTSD患者影像学诊断提供了一个灵敏的生物信号特征。

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