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基于纤维束骨架的空间统计方法研究创伤后应激障碍患者脑白质结构变化

, PP. 2077-2080

Keywords: 创伤后应激障碍,脑白质,弥散张量成像,部分各向异性

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Abstract:

目的探讨创伤后应激障碍(post-traumaticstressdisorder,PTSD)患者大脑白质纤维束的微观变化。方法对9例临床确诊PTSD患者和9例正常对照进行全脑弥散张量成像扫描,应用基于纤维束骨架的空间统计方法(tract-basedspatialstatistics,TBSS)对2组被试白质纤维束的部分各向异性(fractionalanisotropy,FA)值进行比较。结果PTSD患者双侧的钩束、下额枕束、及右侧的额钳、丘脑前辐射、皮质脊髓束的FA值较对照组明显降低(P<0.01)。结论PTSD患者的相关脑区的脑白质FA值的显著下降,提示与记忆、情绪调节相关中枢的脑白质纤维髓鞘结构完整性发生退变或白质纤维数量减少。

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