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TNF-α在实验性蛛网膜下腔出血后早期脑损伤中的作用

, PP. 1620-1622

Keywords: 肿瘤坏死因子-α,蛛网膜下腔出血,早期脑损伤

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Abstract:

目的探讨TNF-α抑制剂在大鼠蛛网膜下腔出血(subarachnoidhemorrhage,SAH)后早期脑损伤中的保护作用及其机制。方法健康成年雄性SD大鼠48只,体质量250~300g,按随机数字表法分为假手术组、SAH组、安慰剂组和TNF-α抑制剂组。采用经视交叉前池注血法建立SAH模型,各组于处理后24h,对实验动物临床行为进行评估;应用免疫组化方法检测大鼠脑皮层TNF-α表达;应用Westernblot方法检测大鼠脑皮层MMP-9蛋白表达。结果免疫组化显示:SAH组大鼠皮层神经元TNF-α表达明显升高,显著高于假手术组;TNF-α抑制剂组TNF-α表达明显下降(P<0.01)。Westernblot检测结果显示:假手术组大鼠MMP-9蛋白表达较低[(2.03±0.21)%];SAH组大鼠皮层MMP-9含量明显升高[(98.92±8.33)%,P<0.01];TNF-α抑制剂组MMP-9蛋白表达降低[(52.12±6.25)%],与SAH组相比差异有统计学意义(P<0.01)。临床行为评估显示:TNF-α抑制剂组大鼠临床行为得到明显改善(P<0.01)。结论大鼠SAH后早期脑损伤过程中TNF-α通过调节MMP-9蛋白表达参与SAH后早期脑损伤的病理过程。TNF-α抑制剂能够改善大鼠临床行为,对早期脑损伤发挥保护作用。

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