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Noggin蛋白对MCF-7细胞增殖、侵袭能力的影响

, PP. 1240-1242

Keywords: Noggin,肿瘤细胞,培养的,细胞系,肿瘤,细胞增殖,肿瘤侵润

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Abstract:

目的观察Noggin蛋白对乳腺癌细胞MCF-7增殖、侵袭能力的影响。方法以Noggin重组腺病毒感染乳腺癌细胞株MCF-7,MTT法检测Noggin对MCF-7细胞增殖能力的影响,划痕修复实验及Transwell细胞侵袭实验检测其运动和侵袭能力的改变,Real-timePCR和Westernblot检测CXCR4和MMP1基因的表达改变。结果过表达Noggin蛋白的MCF-7细胞增殖能力增强(P<0.05);划痕修复实验提示过表达Noggin蛋白的MCF-7细胞划痕愈合延迟;Transwell细胞侵袭实验提示与空病毒组相比,Noggin组穿膜细胞数显著降低(55±4vs25±3,P<0.05)。RT-PCR和Westernblot结果:过表达Noggin后,MCF-7细胞中CXCR4和MMP1基因表达下调。结论Noggin蛋白可抑制乳腺癌细胞MCF-7的运动和迁移,可能与下调CXCR4和MMP1基因的表达相关。

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