Liu W C, Liu Q Y. Molecular mechanisms of gender disparity in hepatitis B virus-associated hepatocellular carcinoma[J]. World J Gastroenterol, 2014, 20(20): 6252-6261. [2]Wei Y, Neuveut C, Tiollais P,et al. Molecular biology of the hepatitis B virus and role of the X gene[J]. Pathol Biol (Paris), 2010, 58(4): 267-272. [3]Wang Y, Cui F, Lv Y,et al. HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice[J]. Hepatology, 2004, 39(2): 318-324. [4]Huang J, Shen L, Lu Y,et al. Parallel induction of cell proliferation and inhibition of cell differentiation in hepatic progenitor cells by hepatitis B virus X gene[J]. Int J Mol Med, 2012, 30(4): 842-848. [5]Okabe M, Tsukahara Y, Tanaka M,et al. Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver[J]. Development, 2009, 136(11): 1951-1960. [6]Wang C, Yang W, Yan H X,et al. Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine-treated HBx transgenic mice[J]. Hepatology, 2012, 55(1): 108-120. [7]Oertel M, Shafritz D A. Stem cells, cell transplantation and liver repopulation[J]. Biochim Biophys Acta, 2008, 1782(2): 61-74. [8]申利红, 芦永良, 李红丽, 等. 乙型肝炎病毒X蛋白对小鼠胚胎肝干细胞凋亡及相关蛋白表达的影响[J]. 中国生物制品学杂志, 2013, 26(6): 771-775, 779. [9]白光文, 申利红, 卢永良, 等. 乙肝病毒X蛋白对肝前体细胞分化的影响[J]. 重庆医科大学学报, 2012, 37(10): 846-849. [10]芦永良, 申利红, 李红丽, 等. HBx诱导小鼠肝前体细胞上皮-间质转化[J]. 细胞与分子免疫学杂志, 2013, 29(2): 146-149. [11]Neuveut C, Wei Y, Buendia M A. Mechanisms of HBV-related hepatocarcinogenesis[J]. J Hepatol, 2010, 52(4): 594-604. [12]吴武佳, 陈李影慧, 宋晨源, 等. CCRK在肝细胞癌组织中的表达及其与HBx的关系[J]. 军事医学, 2013, 37(2): 110-113. [13]Arzumanyan A, Friedman T, Ng I O,et al. Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?[J]. Cancer Res, 2011, 71(10): 3701-3708. [14]Dion S, Bourgine M, Godon O,et al. Adeno-associated virus-mediated gene transfer leads to persistent hepatitis B virus replication in mice expressing HLA-A2 and HLA-DR1 molecules[J]. J Virol, 2013, 87(10): 5554-5563. [15]von-Freyend M J, Untergasser A, Arzberger S,et al. Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B[J]. J Viral Hepat, 2011, 18(3): 216-226. ？
