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Ascl2和microRNA-200家族在结肠癌组织和癌旁组织中的定量表达及二者的相关性分析

, PP. 2377-2379

Keywords: 结肠癌,Ascl,MicroRNA-家族

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Abstract:

目的探讨Ascl2与MicroRNA-200家族在结肠癌(colorectalcancer,CRC)组织及癌旁组织中的表达及二者的相关性。方法采用实时定量PCR检测50例结肠癌患者的结直肠癌组织及其癌旁组织中Ascl2与MicroRNA-200家族表达,用SPSS18.0统计软件进行统计分析。结果Ascl2在癌组织中的表达显著高于癌旁组织(P<0.01),除了MicroRNA-429在癌组织中的表达与癌旁组织相比无统计学差异(P=0.2139),MicroRNA-200家族成员在癌组织中的表达都显著低于癌旁组织(P<0.05);且Ascl2和MicroRNA-200家族成员在癌组织中表达都呈负相关(r<-0.5,P<0.05)。结论发现与正常结直肠黏膜组织相比,Ascl2在结直肠癌组织中表达增高,MicroRNA-200家族表达降低,它们在结直肠癌组织中的表达呈现负相关。

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