全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

预测索拉菲尼治疗晚期原发性肝细胞癌疗效的分子标志物的研究

, PP. 2363-2366

Keywords: 索拉菲尼,原发性肝细胞癌,标志物,VEGFR,pERK

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探寻可能预测索拉菲尼治疗晚期原发性肝细胞癌(hepatocellularcarcinoma,HCC)疗效的分子标志物。方法回顾性分析应用索拉菲尼治疗的54例晚期HCC患者临床资料,将索拉菲尼治疗前病理组织切片分别以抗体VEGFR、pERK、pS6K、PTEN进行免疫组组织化学染色(IHC),根据各抗体染色结果的不同分为高表达组和低表达组,结合索拉菲尼治疗后的疾病进展时间(timetoprogression,TTP)进行对比分析,得到可能预测索拉菲尼治疗HCC疗效的分子标志物。结果VEGFR、pERK高表达组较低表达组的TTP明显延长(P<0.05),PS6K两组之间的TTP无显著差异(P>0.05),PTEN几乎无阳性表达。结论索拉菲尼治疗的肝癌组织中VEGFR、pERK高表达患者能够获得较长的TTP,VEGFR、pERK可能作为预测索拉菲尼治疗晚期HCC疗效的分子标志物。

References

[1]  Llovet J M,? Ricci S,? Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma[J]. N Engl J Med,? 2008, 359(4): 378-390. [2]Cheng A L,? Kang Y K,? Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma:? a phase Ⅲ randomised,? double-blind,? placebo-controlled trial[J]. Lancet Oncol,? 2009, 10(1): 25-34.? [3]Wilhelm S M,? Carter C,? Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis[J]. Cancer Res,? 2004,? 64(19):? 7099-7109.? [4]Wilhelm S M,? Adnane L,? Newell P, et al. Preclinical overview of sorafenib,? a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling[J]. Mol Cancer Ther,? 2008,? 7(10): 3129-3140.? [5]Liu L,? Cao Y,? Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway,? inhibits tumor angiogenesis,? and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5[J]. Cancer Res,? 2006,? 66(24): 11851-11858.? [6] Abou-Alfa G K,? Schwartz L,? Ricci S, et al. Phase Ⅱ study of sorafenib in patients with advanced hepatocellular carcinoma[J]. J Clin Oncol,? 2006,? 24(26): 4293-4300.? [7]Choi M S,? Shim Y H,? Hwa J Y, et al. Expression of DNA methyltransferases in multistep hepatocarcinogenesis[J]. Hum Pathol,? 2003, 34(1): 11-17.? [8]Zhang Z,? Zhou X,? Shen H, et al. Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma:? evidence from an ?in vitro? study[J]. BMC Med,? 2009,? 7: 41. [9]Pinter M,? Sieghart W,? Hucke F, et al. Prognostic factors in patients with advanced hepatocellular carcinoma treated with sorafenib[J]. Aliment Pharmacol Ther,? 2011,? 34(8): 949-959. [10]Worns M A,? Weinmann A,? Pfingst K, et al. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis[J]. J Clin Gastroenterol,? 2009,? 43(5): 489-495.? [11]Kim J E,? Ryoo B Y,? Ryu M H, et al. Sorafenib for hepatocellular carcinoma according to Child-Pugh class of liver function[J]. Cancer Chemother Pharmacol,? 2011,? 68(5): 1285-1290.? [12]Baek K K,? Kim J H,? Uhm J E, et al. Prognostic factors in patients with advanced hepatocellular carcinoma treated with sorafenib:? a retrospective comparison with previously known prognostic models[J]. Oncology, 2011,? 80(3/4): 167-174.? [13]Shim J H,? Park J W,? Choi J I, et al. Practical efficacy of sorafenib monotherapy for advanced hepatocellular carcinoma patients in a Hepatitis B virus-endemic area[J]. J Cancer Res Clin Oncol,? 2009,? 135(4): 617-625.
[2]  李颖,陈平,朱瑾,等.CD105在原发性肝细胞癌血管内皮细胞的表达及临床意义[J].第三军医大学学报,2006,28(07):714.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133