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非小细胞肺癌ERCC1C118T多态性与EGFR突变的相关性

, PP. 184-186

Keywords: 表皮生长因子受体,切除修复交叉互补基因,非小细胞肺癌,化疗,单核苷酸多态性

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Abstract:

目的探讨晚期非小细胞肺癌外周血表皮生长因子受体(epidermalgrowthfactorreceptor,EGFR)激活突变与切除修复交叉互补基因1(excisionrepaircross-complementinggene1,ERCC1)C118T多态性相关性。方法分别利用变性高效液相色谱法和直接测序法分析EGFR激活突变和ERCC1C118T密码子多态性,分析ERCC1118C/C基因型在EGFR野生型和突变型群体中比例差异。结果收集大坪医院肿瘤中心69例晚期非小细胞肺癌病例。ERCC1118C/C基因型在EGFR突变组中比率略高于野生型组(61.5%vs51.8%,P=0.525)。EGFR突变组中ERCC1118C/C比率高于野生型组(OR=1.490,95%CI:0.434~5.118,P=0.527),差异无统计学意义。结论外周血EGFR突变与ERCC1C118T密码子多态性无关。

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