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睡眠剥夺影响大脑情绪功能网络的静息态功能磁共振成像研究

, PP. 2278-2284

Keywords: 睡眠剥夺,杏仁核,静息态,功能连接

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Abstract:

目的探讨睡眠剥夺引起情绪紊乱的大脑功能网络机制。方法采用重复测量自身前后对照设计,利用静息态功能磁共振成像技术,比较睡眠剥夺前后大脑杏仁核3个亚区的全脑功能连接模式表征以及与情绪状态变化的关系。结果睡眠剥夺导致背外侧前额叶、背侧前扣带回、背侧后扣带回以及额下回和杏仁核3个亚区功能连接减弱(P<0.05);后扣带回/楔前叶、内侧前额叶、喙部前扣带回以及海马旁回功能连接上升。与睡眠剥夺前相比,剥夺后POMS总分显著升高,与内侧前额叶和杏仁核SFA区的功能连接强度显著正相关(r=0.415,P<0.05)。结论睡眠剥夺对杏仁核功能连接模式的影响存在明显的区域和网络特异性,杏仁核与默认网络脑区之间的功能连接上升,而与执行控制网络脑区之间的功能连接减弱,可能是睡眠剥夺后情绪调控能力下降的重要神经机制。

References

[1]  Mu Q, Nahas Z, Johnson K A, et al. Decreased Cortical Response to Verbal Working Memory Following Sleep Deprivation[J]. Sleep, 2005, 28(1): 55-67. [2]Durmer J S, Dinges D F. Neurocognitive consequences of sleep deprivation[J]. Semin Neurol, 2005, 25(1): 117-129. [3]Thomas M, Sing H, Belenky G, et al. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity [J]. J Sleep Res, 2000, 9(4): 335-352. [4]Fruhholz S, Grandjean D. Amygdala subregions differentially respond and rapidly adapt to threatening voices[J]. Cortex, 2013, 49(5): 1394-1403. [5]Phelps E A, LeDoux J E. Contributions of the amygdala to emotion processing: from animal models to human behavior[J]. Neuron, 2005, 48(2): 175-187. [6]Ochsner K N, Gross J J. The neural architecture of emotion regulation[M]//Gross J J. Handbook of emotion regulation. New York: Guilford Press, 2007: 87-109. [7]Burghy C A, Stodola D E, Ruttle P L, et al. Developmental pathways to amygdala-prefrontal function and internalizing symptoms in adolescence[J]. Nat Neurosci, 2012, 15(12): 1736-1741. [8]Gee D G, Humphreys K L, Flannery J, et al. A developmental shift from positive to negative connectivity in human amygdala-prefrontal circuitry[J]. J Neurosci, 2013, 33(10): 4584-4593. [9]Kim M J, Gee D G, Loucks R A, et al. Anxiety dissociates dorsal and ventral medial prefrontal cortex functional connectivity with the amygdala at rest[J]. Cereb Cortex, 2011, 21(7): 1667-1673. [10]Banks S J, Eddy K T, Angstadt M, et al. Amygdala-frontal connectivity during emotion regulation[J]. Soc Cogn Affect Neurosci, 2007, 2(4): 303-312. [11]Kohn N, Eickhoff S B, Scheller M, et al. Neural network of cognitive emotion regulation--an ALE meta-analysis and MACM analysis[J]. Neuroimage, 2014, 87: 345-355. [12]Duerden E G, Taylor M J, Soorya L V, et al. Neural correlates of inhibition of socially relevant stimuli in adults with autism spectrum disorder[J]. Brain Res, 2013, 1533: 80-90. [13]Greicius M D, Flores B H, Menon V, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus[J]. Biol Psychiatry, 2007, 62(5): 429-437. [14]Demenescu L R, Kortekaas R, Cremers H R, et al. Amygdala activation and its functional connectivity during perception of emotional faces in social phobia and panic disorder[J]. J Psychiatr Res, 2013, 47(8): 1024-1031. [15]Hahn A, Stein P, Windischberger C, et al. Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder[J]. Neuroimage, 2011, 56(3): 881-889. [16]Hermann A, Schafer A, Walter B, et al. Emotion regulation in spider phobia: role of the medial prefrontal cortex[J]. Soc Cogn Affect Neurosci, 2009, 4(3): 257-267. [17]Selvi Y, Gulec M, Agargun M Y, et al. Mood changes after sleep deprivation in morningness-eveningness chronotypes in healthy individuals[J]. J Sleep Res, 2007, 16(3): 241-244. [18]Rosen I M, Gimotty P A, Shea J A, et al. Evolution of sleep quantity, sleep deprivation, mood disturbances, empathy, and burnout among interns[J]. Acad Med, 2006, 81(1): 82-85. [19]Yoo S S, Gujar N, Hu P, et al. The human emotional brain without sleep--a prefrontal amygdala disconnect[J]. Curr Biol, 2007, 17(20): R877-R878.
[2]  蒋丽珠,刘晨,陈旦,等.条件恐惧刺激对大鼠杏仁核区神经细胞增殖的影响[J].第三军医大学学报,2012,34(03):271.

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