Konglund A, Helseth R, Lund-Johansen M, et al. Surgery for high-grade gliomas in the aging[J]. Acta Neurol Scand, 2013, 128(3): 185-193. [2]Fisher T, Galanti G, Lavie G, et al. Mechanisms operative in the antitumor activity of temozolomide in glioblastoma multiforme[J]. Cancer J, 2007, 13(5): 335-344. [3]Parker K A, Glaysher S, Hurren J, et al. The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures[J]. Anticancer Drugs, 2012, 23(1): 65-69. [4]Levkovitz Y, Gil-Ad I, Zeldich E, et al. Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement[J]. J Mol Neurosci, 2005, 27(1): 29-42. [5]许慧中, 向定朝, 杨伟现, 等. 氯丙咪嗪对人脑胶质瘤U251细胞增殖的影响[J]. 江苏医药, 2012, 38(4): 380-382, 封2. [6]Hendset M, Haslemo T, Rudberg I, et al. The complexity of active metabolites in therapeutic drug monitoring of psychotropic drugs[J]. Pharmacopsychiatry, 2006, 39 (4): 121-127. [7]Pilkington G J, Parker K, Murray S A. Approaches to mitochondrially mediated cancer therapy[J]. Semin Cancer Biol, 2008, 18(3): 226-235. [8]Jeon S H, Kim S H, Kim Y, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells[J]. Biochem Biophys Res Commun, 2011, 413(2): 311-317. [9]Beaney R P, Gullan R W, Pilkington G J. Therapeutic potential of antidepressants in malignant glioma: clinical experience with clomipramine[J]. J Clin Oncol (Meet Abstr), 2005, 23(16S): 1535. [10]Daley E, Wilkie D, Loesch A, et al. Chlorimipramine: a novel anticancer agent with a mitochondrial target[J]. Biochem Biophys Res Commun, 2005, 328(2): 623-632. [11]Bilir A, Erguven M, Oktem G, et al. Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma[J]. Int J Oncol, 2008, 32(4): 829-839.