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银离子表面注入改性硅橡胶抗菌性能及生物相容性的初步研究

, PP. 1914-1920

Keywords: 硅橡胶,离子注入,银离子,表面注入改性,抗菌性,生物相容性

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Abstract:

目的采用银离子对普通硅橡胶进行表面注入改性,以期制备一种抗菌性能及生物相容性良好的整形填充材料。方法用高能离子注入机向普通硅橡胶表面注入银离子,对改性后的硅橡胶采用扫描电子显微镜(scanningelectronmicroscope,SEM)、X射线光电子能谱仪(X-rayphotoelectronspectroscopy,XPS)、傅里叶红外光谱仪(Fouriertransforminfraredspectrometer,FTIR)以及水接触角检测仪对表面形貌、元素组成、化学结构以及亲/疏水性进行检测。选用大肠杆菌进行抑菌圈、抗细菌黏附性实验,初步探究其抗菌性能。采用体外及体内实验对生物相容性进行评价。结果SEM观察各材料的表面形貌无明显差异;XPS结果显示银离子已注入材料表面;FTIR观察各材料图谱无明显变化;水接触角检测结果显示,银离子注入硅橡胶水接触角随注入剂量加大而逐渐变小,逐渐呈现出亲水性趋势。抑菌圈结果显示银离子注入硅橡胶可以使抑菌圈直径>7mm,呈现出抑菌效果;抗细菌黏附性实验显示,改性硅橡胶具有明显的抗菌性。生物相容性评价显示,与普通硅橡胶比,银离子注入硅橡胶均有较好的特性。结论采用银离子注入技术对硅橡胶进行表面改性可以明显提高硅橡胶的亲水性能和抗菌能力以及生物相容性。

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