Jemal A, Bray F, Center M M, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2): 69-90.？ [2]Shih K K, Chi D S. Maximal cytoreductive effort in epithelial ovarian cancer surgery[J]. J Gynecol Oncol 2010, 21: 75-80.？ [3]Torre L A, Bray F, Siegel R L, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2): 87-108.？ [4]Cowap J, Hardy J. Thioridazine in the management of cancer-related sweating[J]. J Pain Symptom Manage, 1998, 15(5): 266.？ [5]Ly K L, Chidgey J, Addington-Hall J, et al. Depression in palliative care: a systematic review. Part 2. Treatment[J]. Palliat Med, 2002, 16(4): 279-284.？ [6]Kamiwatari M, Nagata Y, Kikuchi H, et al. Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photo labeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line[J]. Cancer Res, 1989, 49(12): 3190-3195.？ [7]Pantazaki A A, Lialiaris T S. A combined biochemical and cytogenetic study of thioridazine-induced damage to nucleic acids[J]. Mutagenesis, 1999, 14(2): 243-248.？ [8]Rodrigues T, Santos A C, Pigoso A A, et al. Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms[J]. Br J Pharmacol, 2002, 136(1): 136-142.？ [9]Mu J, Xu H, Yang Y, et al . Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer[J]. Oncol Rep, 2014, 31(5): 2107-2114. [10]Mao M, Yu T, Hu J, et al. Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa[J]. J Obstet Gynaecol Res, 2015, [Epub ahead of print].？ [11]Sullivan L B, Chandel N S. Mitochondrial reactive oxygen species and cancer[J]. Cancer Metab, 2014, 2: 17.？ [12]Klaunig J E, Wang Z, Pu X, et al. Oxidative stress and ？oxidative damage in chemical carcinogenesis[J]. Toxicol Appl Pharmacol, 2011, 254(2): 86-99.？ [13]Huang W, Yang X, Yao S, et al. Reactive oxygen species burst induced by aluminum stress triggers mitochondria-？dependent programmed cell death in peanut root tip cells[J]. Plant Physiol Biochem, 2014, 82: 76-84.？ [14]De-Zio D, Cianfanelli V, Cecconi F. New insights into the link between DNA damage and apoptosis[J]. Antioxid Redox Signal, 2013, 19(6): 559-571.？ [15]Moldoveanu T, Follis A V, Kriwacki R W, et al. Many players in BCL-2 family affairs[J]. Trends Biochem Sci, 2014, 39(3): 101-111.？ [16]Oltrai Z N, Millimau C L, Korsmeyer S J. Bcl-2 heterodimerizes ？in vivo？ with a conserved homolog, Bax, that accelerates programmed Cell death[J]. Cell, 1993, 74( 4): 609-619.？ [17]Wang H, Yang Y, Chen H, et al. The predominant pathway of apoptosis in THP-1 macrophage-derived foam cells induced by 5-aminolevulinic acid-mediated sonodynamic therapy is the mitochondria-caspase pathway despite the participation of endoplasmic reticulum stress[J]. Cell Physiol Biochem, 2014, 33(6): 1789-1801.？ [18]Park M S, Dong S M, Kim B R et al Thioridazine inhibits angiogenesis and tumor growth by targeting the VEGFR-2/PI3K/mTOR pathway in ovarian cancer xenografts[J]. Oncotarget, 2014, 5(13): 4929-4934.？ [19]Sachlos E, Risueno R M, Laronde S, et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells[J]. Cell, 2012, 149(6): 1284-1297.？ [20]Gatto F, Hofland L J. The role of somatostatin and dopamine D2 receptors in endocrine tumors[J]. Endocr Relat Cancer, 2011, 18(6): R233-R251.？ [21]Gil-Ad I, Shtaif B, Levkovitz Y, et al. Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth[J]. Oncol Rep, 2006, 15(1): 107-112. ？
