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宁夏地区成人化脓性脑膜炎脑脊液细菌构成及特点

, PP. 1684-1687

Keywords: 成人化脓性脑膜炎,脑脊液,细菌培养

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Abstract:

目的分析宁夏地区成人化脓性脑膜炎(purulentmeningitisinadult,APM)脑脊液细菌构成,并探讨其细菌培养阳性患者的特点。方法收集我院近13年来收治的201例APM患者的临床资料,回顾性分析144例行细菌培养的脑脊液细菌构成并比较致病菌检出阳性病例(CP组)与阴性病例(CN组)的临床及实验室特点。结果APM的细菌检出阳性率为36.81%,致病菌以革兰阳性球菌常见(64.15%),其中以凝固酶阴性葡萄球菌最多,金黄色葡萄球菌次之;CP组年龄、男性病例数、以意识障碍及癫痫发作表现者显著高于CN组(P<0.05),且其血中性粒细胞比例、脑脊液白细胞计数及脑脊液蛋白含量均较CN组高(P<0.05);在发病10d内就诊的患者,CP组脑脊液压力、脑脊液白细胞计数、脑脊液中性粒细胞比例均较CN组高,脑脊液淋巴细胞比例较CN组低(P<0.05)。结论成人APM的致病菌以革兰阳性球菌多见,其细菌培养阳性患者的临床特点与培养阴性者有差异,可早期预测细菌培养结果。

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