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S100A4、SEPT7在儿童神经胶质瘤的表达特点及临床意义

, PP. 1673-1676

Keywords: 神经胶质细胞瘤,儿童,SA,SEPT,免疫组织化学

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Abstract:

目的研究儿童神经胶质瘤中S100A4、SEPT7的表达并比较其表达特点,探讨其在儿童神经胶质瘤中的表达与病理分级间的关系及临床意义。方法采用免疫组化(S-P法)检测10例儿童正常脑组织标本和37例儿童脑神经胶质瘤标本中S100A4、SEPT7的表达,计算其阳性细胞的标记指数和阳性细胞表达率,通过SPSS17.0分析儿童神经胶质瘤中S100A4、SEPT7的表达和儿童神经胶质瘤病理分级的相关性。结果S100A4呈棕黄色颗粒散在分布,在细胞质和细胞间质中阳性表达。在儿童神经胶质瘤组织中表达率为72.97%,在儿童正常对照组织中未见明显表达,病理分级与S100A4的阳性表达呈正相关(r=0.800,P<0.05)。SEPT7蛋白在儿童脑神经胶质细胞瘤中的表达主要存在细胞质内,在儿童正常脑组织中的表达为100.00%,在神经胶质瘤组织中表达率为54.05%,病理分级与SEPT7的阳性表达呈负相关(r=-0.674,P<0.05)。S100A4和SEPT7两者在同一级别儿童胶质瘤中的表达呈负相关(r=-0.617,P<0.01)。结论联合检测儿童神经胶质瘤S100A4和SEPT7的蛋白表达对评估儿童胶质瘤的恶性程度有重要的参考意义。

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