Xie W, Wan O W, Chung K K. New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson’s disease[J]. Biochim Biophys Acta, 2010, 1802(11): 935-941. [2]Mammucari C, Rizzuto R. Signaling pathways in mitochondrial dysfunction and aging[J]. Mech Ageing Dev, 2010, 131(7/8): 536-543. [3]Recasens A, Dehay B. Alpha-synuclein spreading in Parkinson's disease[J]. Front Neuroanat, 2014, 8: 159. [4]McNaught K S, Olanow C W. Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson’s disease[J]. Ann Neurol, 2003, 53(Suppl 3): S73-S84. [5]Martinez-Vicente M, Cuervo A M. Autophagy and neurodegeneration: when the cleaning crew goes on strike[J]. Lancet Neurol, 2007, 6(4): 352-361. [6]Rubinsztein D C. The roles of intracellular protein-degradation pathways in neurodegeneration[J]. Nature, 2006, 443(7113): 780-786. [7]Sahu R, Kaushik S, Clement C C, et al. Microautophagy of cytosolic proteins by late endosomes[J]. Dev Cell, 2011, 20(1): 131-139. [8]Furlong R A, Narain Y, Rankin J, et al. Alpha-synuclein overexpression promotes aggregation of mutant huntingtin[J]. Biochem J, 2000, 346(Pt 3): 577-581. [9]Stefanis L, Larsen K E, Rideout H J, et al. Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death[J]. J Neurosci, 2001, 21(24): 9549-9560. [10]韩起, 陈莎, 杨明珍, 等. 溶酶体相关膜蛋白2A shRNA对乳腺癌细胞株紫杉醇耐药的影响[J]. 细胞与分子免疫学杂志, 2014, 30(4): 351-354. [11]Martinez-Vicente M. Multiple ways for a-synuclein degradation[J]. Mov Disord, 2012, 27(3): 345. [12]Cuervo A M, Wong E. Chaperone-mediated autophagy: roles in disease and aging[J]. Cell Res, 2014, 24(1): 92-104. [13]Cuervo A M, Stefanis L, Fredenburg R, et al. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy[J]. Science, 2004, 305(5688): 1292-1295. [14]Kaushik S, Cuervo A M. Chaperone-mediated autophagy: a unique way to enter the lysosome world[J]. Trends Cell Biol, 2012, 22(8): 407-417. [15]Kissova I, Salin B, Schaeffer J, et al. Selective and non-selective autophagic degradation of mitochondria in yeast[J]. Autophagy, 2007, 3(4): 329-336. [16]Farre J C, Krick R, Subramani S, et al. Turnover of organelles by autophagy in yeast[J]. Curr Opin Cell Biol, 2009, 21(4): 522-530. [17]Bourdenx M, Bezard E, Dehay B. Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death[J]. Front Neuroanat, 2014, 8: 83. [18]Yang Q, She H, Gearing M, et al. Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy[J]. Science, 2009, 323(5910): 124-127. [19]Shacka J J, Klocke B J, Roth K A. Autophagy, bafilomycin and cell death: the “a-B-cs” of plecomacrolide-induced neuroprotection[J]. Autophagy, 2006, 2(3): 228-230. [20]Klionsky D J, Abdalla F C, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring auto-phagy[J]. Autophagy, 2012, 8(4): 445-544. [21]Massey A C, Kaushik S, Sovak G, et al. Consequences of the selective blockage of chaperone-mediated autophagy[J]. Proc Natl Acad Sci U S A, 2006, 103(15): 5805-5810. [22]Kaushik S, Cuervo A M. Methods to monitor chaperone-mediated autophagy[J]. Methods Enzymol, 2009, 452: 297-324. [23]Falguieres T, Luyet P P, Bissig C, et al. ?In vitro? budding of intralumenal vesicles into late endosomes is regulated by Alix and Tsg101[J]. Mol Biol Cell, 2008, 19(11): 4942-4955. [24]李霞, 黄文娟, 朱素菲, 等. 雷帕霉素诱导细胞自噬促进乙型肝炎病毒的复制[J]. 第三军医大学学报, 2014, 36(12): 1233-1236. ?