Samani A A, Yakar S, LeRoith D, et al. The role of the IGF system in cancer growth and metastasis:？ overview and recent insights[J]. Endocr Rev, 2007, 28(1): 20-47. [2]Adachi Y, Li R, Yamamoto H, et al. Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers ？via？ blocking production of matrilysin[J]. Carcinogenesis, 2009, 30(8):？ 1305-1313. [3]Shen K, Liang Q, Xu K, et al. MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor[J]. Biochem Pharmacol, 2012, 84(3): 320-330. [4]Ma J, Sawai H, Matsuo Y, et al. IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells[J]. J Surg Res, 2010, 160(1): 90-101. [5]Liu C H, Bao H G, Ge Y L, et al. Celecoxib inhibits insulin-like growth factor 1 induced growth and invasion in non-small cell lung cancer[J]. Oncol Lett, 2013, 5(6): 1943-1947. [6]Dunn S E, Torres J V, Oh J S, et al. Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase[J]. Cancer Res, 2001, 61(4): 1367-1374. [7]唐茂源, 霍钢, 冯清林, 等. uPA和uPAR在侵袭性垂体腺瘤中的表达及意义[J]. 中国神经精神疾病杂志, 2010, 36(9): 547-549. [8]于烽, 苏国军, 俞文华. 骨桥蛋白与基质金属蛋白酶-2在垂体腺瘤中的表达及意义[J]. 实用医学杂志, 2011, 27(9): 1559-1562. [9]Simes J M, Wallace J C, Walton P E. The effects of insulin-like growth factor-I (IGF-I), IGF-II and des(1-3)IGF-I, a potent IGF analogue, on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells[J]. J Endocrinol, 1991, 130(1): 93-99. [10]Fruchtman S, McVey D C, Borski R J. Characterization of pituitary IGF-I receptors:？ modulation of prolactin and growth hormone[J]. Am J Physiol Regul Integr Comp Physiol, 2002, 283(2): R468-R476. [11]Saitoh Y, Hikake T, Hayashi S, et al. Involvement of insulin-like growth factor-I for the regulation of prolactin synthesis by estrogen and postnatal proliferation of lactotrophs in the mouse anterior pituitary[J]. Cell Tissue Res, 2010, 340(1): 147-158. [12]Furukawa M, Raffeld M, Mateo C, et al. Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases[J]. Clin Cancer Res, 2005, 11(9): 3233-3242. [13]Valsecchi M E, McDonald M, Brody J R, et al. Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma[J]. Cancer, 2012, 118(14):？ 3484-3493. [14]谢庆祥, 林吓聪, 张闽峰, 等. IGF-I和IGF-IR在膀胱癌组织中表达的意义[J]. 癌症, 2004, 23(6): 707-709. [15]Yamamoto T, Oshima T, Yoshihara K, et al. Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer[J]. Exp Ther Med, 2012, 3(5): 797-802. [16]Spiliotaki M, Markomanolaki H, Mela M, et al. Targeting the insulin-like growth factor I receptor inhibits proliferation and VEGF production of non-small cell lung cancer cells and enhances paclitaxel-mediated anti-tumor effect[J]. Lung Cancer, 2011, 73(2): 158-165. [17]Adachi Y, Ohashi H, Imsumran A, et al. The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma[J]. Tumour Biol, 2014, 35(2): 973-985. [18]Rubinfeld H, Kammer A, Cohen O, et al. IGF1 induces cell proliferation in human pituitary tumors-functional blockade of IGF1 receptor as a novel therapeutic approach in non-functioning tumors[J]. Mol Cell Endocrinol, 2014, 390(1/2): 93-101.
[2]
赵雪峰,焦志凯,李勇,等.胃癌中PTEN、IGF-1、IGF-1R蛋白表达及其预后意义评价[J].第三军医大学学报,2008,30(12):1197. ZHAO Xue-Feng,JIAO Zhi-Kai,LI Yong,et al.Expressions and significances of PTEN，IGF-1 and IGF-1R in gastric cancer[J].J Third Mil Med Univ,2008,30(13):1197.
