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多孔钽颗粒在下颌骨缺损修复中的作用

, PP. 1277-1280

Keywords: 多孔钽颗粒,Bio-oss骨粉,颌骨缺损,修复效果

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Abstract:

目的评价多孔钽颗粒对下颌骨骨缺损的修复效果。方法首先拔出比格犬双侧下颌前磨牙,待拔牙创愈合后(3个月)采用牙科种植机在下颌骨缺牙区构建颌骨骨缺损模型,随即将多孔钽颗粒(实验组,n=9)和Bio-oss骨粉(对照组,n=9)分别植入右侧和左侧下颌骨骨缺损区内。半流食喂养3个月后,双侧下颌骨行X线摄片比较2组材料修复骨缺损的能力,然后采用EXAKT切磨机制取硬组织切片,行甲苯胺蓝染色后于显微镜下观察新骨成熟情况。结果3个月后,大体标本和X线摄片发现:实验组和对照组颌骨骨缺损区内均有新骨生成;按照X线评分标准对骨形成及塑形情况进行评价发现:实验组评分高于对照组[(9.54±0.10)vs(8.98±0.09),P<0.05],差异有统计学意义。硬组织切片染色观察发现:实验组缺损区骨组织较对照组更为成熟,且包绕了大量的多孔钽颗粒,其相互交联呈网状;虽然对照组(Bio-oss骨粉颗粒)周围有较成熟的骨组织包绕,但颗粒之间仍有大量骨陷窝存在。结论实验结果显示多孔钽颗粒具有良好的诱导成骨能力,其修复颌骨缺损效果优于临床常用的Bio-oss骨粉。

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