Gibbons J J, Abraham R T, Yu K. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth[J]. Semin Oncol, 2009, 36(Suppl 3): S3-S17.？ [2]Sato T, Nakashima A, Tamanoi F. Rheb-mTOR signaling pathway involved in tumor formation[J]. Tanpakushitsu Kakusan Koso, 2010, 55(1): 11-17.？ [3]Martelli A M, Evangelisti C, Chappell W, et al. Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway[J]. Leukemia, 2011, 25(7): 1064-1079.？ [4]熊敏琪, 陈瑜, 张腾. 三七皂苷临床应用的基础研究进展[J]. 中医药信息, 2014, 31(3): 149-153.？ [5]He F, Ding Y, Liang C, et al. Antitumor effects of dammarane-type saponins from steamed Notoginseng[J]. Pharmacogn Mag, 2014, 10(39): 314-317.？ [6]邹存华, 付婷婷, 鲁强, 等. 三七总皂苷抑制Hela细胞增殖的实验研究[J]. 中华肿瘤防治杂志, 2012, 19(12): 888-891. [7]倪晓辰, 赵志红, 仇炜, 等. 三七总皂苷对前列腺癌PC-3细胞增殖及迁移的抑制作用[J]. 中国肿瘤临床, 2011, 38(11): 638-641.？ [8]文玲玲, 肖彬, 周辉. 三七总皂苷对三种不同人肝癌细胞株增殖的影响[J]. 肿瘤药学, 2013, 3(2): 100-103, 125.？ [9]Wang C Z, Xie J T, Fishbein A, et al. Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells[J]. Phytother Res, 2009, 23(1): 6-13. [10]Wang P, Cui J, Du X, et al. Panax notoginseng saponins (PNS) inhibits breast cancer metastasis[J]. J Ethnopharmacol, 2014, 154(3): 663-671.？ [11]Rumjanek V M, Vidal R S, Maia R C. Multidrug resistance in chronic myeloid leukaemia: how much can we learn from MDR-CML cell lines[J]. Biosci Rep, 2013, 33(6): e00081.？ [12]Vakana E, Sassano A, Platanias L C. Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells[J]. Autophagy, 2010, 6(7): 966-967.？ [13]Cilloni D, Sagilo G. Molecular pathway: BCR-ABL[J]. Clin Cancer Res, 2012, 18(4): 930-937.？ [14]Machado-Neto J A, Favaro P, Lazarini M, et al. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cell[J]. Biochim Biophys Acta, 2011, 1813(8): 1404-1411.？ [15]崔玲玲, 尹利明, 郑智茵. 三七总皂苷联合阿糖胞苷对K562细胞的影响[J]. 浙江中医药大学学报, 2012, 36(9): 1025-1028.？ [16]王远航, 祝延, 张翠玲, 等. 三七总皂苷联合环磷酰胺节律化疗抗肿瘤效应观察[J]. 北京中医药大学学报, 2010, 33(1): 36-40, 插3.
[2]
杨永长,传良敏,黄文芳,等.辛伐他汀抑制K562细胞MAPK1、cyclin D1、E2F1、c-myc mRNA的表达[J].第三军医大学学报,2009,31(03):241. YANG Yong-chang,CHUAN Liang-min,HUANG Wen-fang,et al.Simvastatin down-regulates mRNA expressions of MAPK1, cyclin D1, E2F1 and c-myc in K562 cells[J].J Third Mil Med Univ,2009,31(12):241. [2]许晓风,李爽,李昊淼.K562细胞对树突状细胞线粒体功能和能量代谢状态的影响[J].第三军医大学学报,2015,37(18):1854. Xu Xiaofeng,Li Shuang,Li Haomiao.K562 cells impair mitochondrial function and energy metabolism of dendritic cells in Transwell coculture system[J].J Third Mil Med Univ,2015,37(12):1854. [3]舒燕,齐杰玉,王灿蔚,等.MicroRNA-193b对K562细胞bcr/abl表达的影响[J].第三军医大学学报,2015,37(19 ):1955. Shu Yan,Qi Jieyu,Wang Canwei,et al.MicroRNA-193b down-regulates bcr/abl in K562 cells[J].J Third Mil Med Univ,2015,37(12):1955. [4]周定安,黄文芳,刘文,等.P53途径在辛伐他汀诱导K562细胞凋亡中的作用[J].第三军医大学学报,2007,29(22):2160. ZHOU Ding-an,HUANG Wen-fang,LIU Wen,et al.Role of P53 pathway in simvastatin-induced apoptosis of K562 cells in vitro[J].J Third Mil Med Univ,2007,29(12):2160. [5]周定安,黄文芳,张明川,等.辛伐他汀对K562细胞PI3K-AKT信号通路分子变化影响的体内外比较[J].第三军医大学学报,2007,29(21):2049. ZHOU Ding-an,HUANG Wen-fang,ZHANG Ming-chuan,et al.Molecular changes of PI3K-AKT signal pathway in K562 cells treated with simvastatin in vitro and in vivo[J].J Third Mil Med Univ,2007,29(12):2049. [6]袁媛,李招权,司维柯,等.Wnt5a与髓细胞白血病发生关系的研究[J].第三军医大学学报,2007,29(21):2056. YUAN Yuan,LI Zhao-quan,SI Wei-ke,et al.Correlation between myeloid leukemia development and Wnt5a expression[J].J Third Mil Med Univ,2007,29(12):2056. [7]李招权,司维柯,邹全明,等.外源性Wnt5a激活K562细胞非经典Wnt5a/Ca2+信号途径研究[J].第三军医大学学报,2008,30(10):924. LI Zhao-quan,SI Wei-ke,ZOU Quan-ming,et al.Noncanonical Wnt5a/Ca2+ pathway activated by exogenous Wnt5a in K562 cells[J].J Third Mil Med Univ,2008,30(12):924. [8]何鹏,骆展鹏,张伶,等.RNAi重组体抑制白血病K562细胞系中NPM1基因的表达[J].第三军医大学学报,2008,30(10):938. HE Peng,LUO Zhan-peng,ZHANG Ling,et al.RNA interference silencing nucleophosmin 1 inhibits NPM1 gene expression in K562 cells[J].J Third Mil Med Univ,2008,30(12):938. [9]林雪梅,田雪莲,杨慧,等.青蒿琥酯对K562细胞和脐血CD34+造血干/祖细胞的选择性作用[J].第三军医大学学报,2007,29(20):1939. LIN Xue-mei,TIAN Xue-lian,YANG Hui,et al.Selective effect of artesunate on K562 cell and CD34+ hematopoietic stem/progenitor cell from umbilical cord blood[J].J Third Mil Med Univ,2007,29(12):1939. [10]罗颖,温贤浩,徐酉华.K562细胞survivin基因表达对淋巴细胞增殖和功能的影响[J].第三军医大学学报,2008,30(23):2215. LUO Ying,WEN Xian-hao,XU You-hua.Effect of enhanced survivin expression on lymphocyte proliferation and function in K562 cells[J].J Third Mil Med Univ,2008,30(12):2215.
