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空腹血糖受损患者胰岛素抵抗与血压的关系

, PP. 1150-1154

Keywords: 空腹血糖受损,胰岛素抵抗,高血压

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Abstract:

目的观察空腹血糖受损患者的胰岛素抵抗与血压的关系。方法选取2012年10月至2013年8月西南医院内分泌科门诊及体检中心的空腹血糖受损患者180例,测定血压后分为血压正常组[n=88,年龄(45.9±12.5)岁,其中男性43例、女性45例]及高血压组[n=92,年龄(44.9±12.5)岁,其中男性47例,女性45例],两组均给予生活方式干预指导,高血压组给予常用降压治疗,对比分析两组患者空腹血糖、OGTT2h血糖、空腹胰岛素、OGTT2h胰岛素、糖化血红蛋白,并计算胰岛素抵抗指数HOMA-IR的变化情况。结果高血压组患者胰岛素抵抗指数HOMA-IR升高较血压正常组患者明显[(4.4±1.3)vs(3.2±0.8),P<0.05]。治疗6个月后,血压正常组患者的各项指标无明显变化(P>0.05);高血压组空腹胰岛素(11.2±2.5)、HOMA-IR(3.3±0.7)明显降低(P<0.05),其中66例患者血压控制达标(BP<130/80mmHg),18例血压控制未达标。血压达标亚组空腹胰岛素(10.5±2.4)、胰岛素抵抗指数HOMA-IR(2.9±0.6)均较未达标亚组空腹胰岛素(13.7±2.6)、胰岛素抵抗指数HOMA-IR(4.0±0.8)显著降低(P<0.05)。结论空腹血糖受损伴高血压患者胰岛素抵抗明显,该部分人群胰岛素抵抗可能与血压升高有关,血压控制达标可改善空腹血糖受损人群的胰岛素抵抗。

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