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小剂量多次注射可增强艾塞那肽对2型糖尿病患者的治疗效果

, PP. 1155-1160

Keywords: 艾塞那肽,小剂量多次注射,血糖,糖尿病

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Abstract:

目的探讨艾塞那肽小剂量多次注射对2型糖尿病患者的疗效及安全性。方法选择2014年1-7月在西南医院内分泌科住院的2型糖尿病患者23例,其中男性12例、女性11例,平均年龄49.2岁,随机分为艾塞那肽2针治疗组12例,3针治疗组11例,比较治疗前后6个月体质量、BMI、腰围、腰臀比、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹及餐后C肽、自我血糖监测(SMBG)、总胆固醇(Tch)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血肌酐(Cr)、尿素氮(UN)。结果两组体质量、腰围、腰臀比、FPG、PPG、HbA1c、Tch、TG、LDL-C、HDL-C均较治疗前有所下降,组间比较差异无统计学意义(P>0.05),两组患者治疗后BMI较治疗前明显下降,其中3针治疗组患者BMI下降较2针治疗组明显,差异具有统计学意义(P<0.05),两组患者治疗后SMBG均较治疗前明显下降,3针治疗组患者午餐后血糖[(12.56±1.32)mmol/L]及睡前血糖[(8.97±1.07)mmol/L]较2针治疗组的午餐后血糖[(13.25±1.23)mmol/L]、睡前血糖[(9.78±0.70)mmol/L]更低,且差异具有统计学意义(P<0.05)。结论每天3次5μg艾塞那肽注射更有利于2型糖尿病患者餐后血糖的控制。

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