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急性缺血性脑卒中短期强化内科治疗的早期再灌注特点

, PP. 921-924

Keywords: 缺血性脑血管病,强化内科治疗,动脉自旋标记,再灌注

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Abstract:

目的比较急性缺血性卒中(acuteischemicstroke,AIS)强化内科治疗前后早期再灌注变化。方法15例发生在大脑半球一侧的急性缺血性卒中患者,分别在强化内科治疗前及治疗后24h行磁共振动脉自旋标记(arterialspinlabeling,ASL)灌注检查。利用SPM8软件对获得的脑血流图像进行预处理并统计分析,比较治疗前后脑血流量的变化,并对患者进行90d的随访,主要结局为基于意向性治疗分析的90d任何卒中事件。结果15例患者经强化药物治疗后第7天,NIHSS评分从治疗前的(7.20±2.76)明显减低为(5.47±2.56)(P<0.01);随访第90天患者mRS评分从治疗前(3.93±0.26)减低为(3.00±0.66)(P<0.05)。所有患者无终点事件发生。ASL结果显示:与治疗前相比,患者治疗后24h部分梗死区域局部脑血流量(rCBF)明显增加(P<0.05)。结论强化药物治疗能够改善急性缺血性卒中患者早期部分缺血部位的脑血流量,提高再灌注水平。

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