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可降解涂层与永久性涂层药物洗脱支架治疗冠心病合并糖尿病患者的有效性及安全性研究

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Keywords: 冠心病,糖尿病,冠状动脉介入治疗,药物洗脱支架,可降解涂层

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Abstract:

目的比较可降解涂层与永久性涂层药物洗脱支架治疗冠心病合并糖尿病患者的远期疗效及安全性。方法回顾性分析2008年1月至2012年12月我院确诊为冠心病合并糖尿病并行经皮冠状动脉介入治疗(percutaneouscoronaryintervention,PCI)的患者364例,男性261例,女性103例,145例植入可降解涂层药物洗脱支架,219例植入永久性涂层药物洗脱支架;对比术后两组患者主要不良心血管事件(mainadversecardiacevents,MACE)的发生情况。结果两组患者在临床一般基线资料、冠脉病变特征等方面均无统计学差异(P>0.05)。可降解涂层组与永久性涂层组相比,两组在心源性死亡(1.4%vs1.9%)、非致死性心肌梗死(0.7%vs0.9%)、支架内血栓(2.1%vs2.3%)、靶血管血运重建(2.8%vs2.8%)方面差异均无统计学意义(P>0.05)。结论永久性涂层药物洗脱支架和可降解涂层药物洗脱支架治疗冠心病合并糖尿病患者均有效,且两者安全性无明显差异。

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